ArticleOsteoarthritis and cartilage open2026
Lower limb malalignment on whole-leg radiography predicts medial or lateral talar osteochondral lesion location: Implications for osteoarthritis assessment.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the association between coronal plane malalignment of the lower extremity and talar osteochondritis dissecans (OCD) localization, and assess the influence of mechanical axis deviations and local joint morphology on lesion distribution. Design: This retrospective monocentric study included 50 patients (mean age 31 ± 12 years) with 52 talar OCD lesions who underwent standing whole-leg radiography, which were analyzed digitally. The primary outcome was OCD lesion localization (medial vs. lateral) in relation to coronal plane lower limb alignment (varus, neutral, valgus). Secondary outcomes included angular parameters of the knee and ankle (mLDFA, mMPTA, mLDTA, JLCA, KAJA, talar inclination, talar tilt) and associations lower limb alignment patterns with lesion location. Associations were assessed via univariate testing and binary logistic regression. Results: Talar OCDs occurred medially in 83 % and laterally in 17 %. Lower limb malalignment was significantly associated with lesion localization (p = 0.024), with varus correlated with medial, while valgus predicted lateral OCD lesions (OR 2.63; 95 % CI 1.1-6.4; p = 0.034). Talar tilt independently correlated with lesion site (p < 0.001); tibiotalar valgus tilt increased odds for lateral lesions (OR 0.084; 95 % CI 0.01-0.73; p = 0.025). Combined knee and ankle alignment subtypes also influenced lesion laterality (p = 0.017). Conclusions: Lower limb malalignment and talar tilt are independent predictors of OCD localization. Coronal plane deviations and joint morphology alter load across the talar dome, contributing to medial or lateral predilection. Whole-leg alignment analysis should be considered in diagnostic and surgical planning, particularly in revision cases.
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