ArticleFrontiers in medicine2025
Effect of sevoflurane post-conditioning on postoperative cognitive function in carotid endarterectomy patients: a randomized, double-blind, controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04950205 (The Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study evaluated the effect of low-dose sevoflurane post-conditioning on early neurocognitive recovery in patients aged 50-80 years undergoing carotid endarterectomy (CEA). Methods: In this randomized, double-blind, single-center trial, 71 patients undergoing elective CEA receiving either sevoflurane post-conditioning (Group S, Results: The two-way repeated-measures ANOVA revealed a significant main effect of group for both MMSE ( Conclusion: Low-dose sevoflurane post-conditioning provides superior short-term preservation of cognitive function compared to standard anesthesia in patients undergoing CEA. These findings support the potential neuroprotective role of sevoflurane post-conditioning. Further research is warranted to explore long-term outcomes that incorporate biological sample testing. Clinical trial registration: https://ClinicalTrials.gov, NCT04950205.
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