ArticleThe breast journal2025
Adherence to Aromatase Inhibitor Therapy in Breast Cancer: Insights From a Multicenter Italian Study.
Article in The breast journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Lower-Cost Nonsurgical Primary Prevention Strategies for Women at High Risk of Breast Cancer: A Scoping Review.The breast journal · 2026Article
- Management Strategies for Aromatase Inhibitor-Associated Musculoskeletal Symptoms and Their Impact on Treatment Persistence in Postmenopausal Breast Cancer: A Single-Center Retrospective Cohort Study.International journal of women's health · 2026Article
- Adherence to Aromatase Inhibitor Therapy in Breast Cancer: Insights From a Multicenter Italian Study.The breast journal · 2025Article
Corrections and comments
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In estrogen-receptor positive breast cancer (BC), oral adjuvant endocrine therapy (ET) administered for at least 5 years significantly reduces risks of disease recurrence and mortality. Among available therapies, aromatase inhibitors (AI) showed high efficacy. However, adherence to ET is very poor. Effective support by physicians requires the identification of factors influencing AI treatment adherence. Materials and Methods: A prospective/retrospective multicentric study was conducted in adult BC women currently undergoing adjuvant treatment with AI. Study endpoints were assessed through a questionnaire after at least 12 months of adjuvant therapy. The primary objective was the assessment of the adherence to AI; secondary objectives were the assessment of adverse events (AEs) of the therapy and the solutions adopted for AEs. Results: Overall, 903 patients with a median age of 63 years were enrolled. Two hundred and forty-three patients (26.9%) stated they do not respect the intake times. Adherence was not influenced by the number of drugs other than the ones for BC or by age. Most patients (87%) suffered from one or more AEs. The most frequent are musculoskeletal symptoms, which occurred in 86.2% of the patients. 74.5% and 74.4% of participants reported hot flashes and tiredness, respectively. No structured or uniform responses were reported regarding the strategy for solving side effects: answers were almost generic, but for more than 50% of patients, the final outcome was positive. AEs were a driver for nonadherence in only 19.6% of patients. Conclusion: Survey results should be considered as an overview of AI therapy adherence in BC patients. We showed that the oncologist has a key role in improving therapeutic adherence and, as a consequence, in improving clinical outcome. Through a dialogue with the patient and a synergistic interaction with other clinical specialists, a greater awareness of the importance of the treatment could be warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.