ArticleClinical and translational radiation oncology2026
Evaluation of loco-regional recurrences using deformable image registration after isotoxic high dose stereotactic body radiotherapy in localised pancreatic cancer.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evaluation of the efficacy of plan adaptation in stereotactic body proton therapy for pancreatic cancer.Journal of applied clinical medical physics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Purpose: Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with poor survival outcomes. Neoadjuvant treatments, including radiotherapy, have been developed to improve resectability and survival rates. This study evaluates loco-regional recurrence (LRR) patterns after isotoxic high-dose stereotactic body radiotherapy (iHD-SBRT) for localized pancreatic cancer using deformable image registration (DIR). Materials and Methods: Patients with borderline/locally advanced pancreatic adenocarcinoma treated between January 2018 and January 2021 were included. Treatment involved modified FOLFIRINOX chemotherapy, iHD-SBRT, and surgery, if feasible. LRRs identified via CT/MRI during follow-up were mapped back onto initial radiotherapy planning using validated DIR workflows. Recurrences were classified as in-field (IF), marginal (M), or out-of-field (OF). Results: Among 41 patients, LRRs were identified in 17 (10 via CT, 7 via MRI). The majority of LRRs were classified as OF (53 %, n = 9), with 23.5 % (n = 4) each in IF and M categories. Marginal recurrences were located near major abdominal vessels, such as the superior mesenteric artery and coeliac artery. DIR quality metrics, including DICE and MDA, validated the accuracy of the mapping process. Conclusion: Image based evaluation of loco-regional recurrence is an important part of the assessment of patients treated with iHD-SBRT for localised pancreatic cancer. DIR-based analysis emphasized the importance of expanding the tumor-vessel interface (TVI) structure in radiotherapy planning to include the full circumference of adjacent vessels with a 5 mm margin. DIR-based analysis highlighted that several marginal recurrences occurred in proximity to perivascular regions, suggesting a potential benefit of expanding perivascular target coverage in future treatment planning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.