Evidence map›Paper›PMID 41438079›Full record

ReviewiScience2025

Cartilage organoids from basic research to clinical translation.

Wenyi Zhang, Lin Chen, Yuzhen Li, Di Zhang, Nan Wang, Xueyong Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenyi ZhangDepartment of Rehabilitation, Shengjing Hospital of China Medical University, No.16 Puhe Road, Shenbei New District, Shenyang, Liaoning Province, China.
Lin ChenDepartment of Rehabilitation, Shengjing Hospital of China Medical University, No.16 Puhe Road, Shenbei New District, Shenyang, Liaoning Province, China.
Yuzhen LiDepartment of Physical Medicine and Rehabilitation, Second Clinical College of China Medical University, Shenyang, Liaoning, China.
Di ZhangDepartment of Rehabilitation, Shengjing Hospital of China Medical University, No.16 Puhe Road, Shenbei New District, Shenyang, Liaoning Province, China.
Nan WangDepartment of Physical Medicine and Rehabilitation, Second Clinical College of China Medical University, Shenyang, Liaoning, China.
Xueyong LiuDepartment of Rehabilitation, Shengjing Hospital of China Medical University, No.16 Puhe Road, Shenbei New District, Shenyang, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage organoids (COs) represent an emerging model system that advances joint repair and tissue regeneration research. These three-dimensional models overcome the limitations of traditional monolayer culture by preserving chondrocyte phenotype and metabolic function, while also modeling pathological microenvironments like osteoarthritis. This capability positions COs as powerful tools for investigating disease mechanisms and screening therapeutic agents. Furthermore, when integrated with microfluidics, bioprinting, and mechanical loading systems, COs exhibit significant potential for applications in personalized tissue engineering. This review synthesizes recent progress in the CO field, critically assesses its translational promise for biomedical applications, and outlines the prevailing challenges and key future research directions.

Indexed as

Health sciencesHealth technology

Identifiers

PMID41438079
PMCPMC12719067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.