Evidence map›Paper›PMID 41438070›Full record

ArticleiScience2025

Fiber enrichment is not superior to dietary monitoring in MASLD: A dual-center, double-blind, placebo-controlled trial.

Annette Brandt, Timur Yergaliyev, Emina Halibasic, Aline Cyba, Julius W Jaeger, Rongpeng Gong, Angélica Hernández-Arriaga, Carolin Victoria Schneider, Wilhelm Sjöland, Antonio Molinaro and 5 more

Registry-linked trialAbstract read
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In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03897218 (Dietary Modulation of Intestinal Microbiota as Trigger of Liver Health), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03897218 nacompletednot on this map

Dietary Modulation of Intestinal Microbiota as Trigger of Liver Health: Role of Bile Acids - "A Diet for Liver Health (ADLH)"

TypeinterventionalSponsorRWTH Aachen UniversityRan2019 to 2022Enrolled84ConditionsNASH - Nonalcoholic SteatohepatitisArmsoatmeal flakes with prebiotic food supplements, millet flakes
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Annette BrandtDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Timur YergaliyevLivestock Microbial Ecology Department, Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.
Emina HalibasicDivision of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Aline CybaDepartment of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Julius W JaegerDepartment of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Rongpeng GongDepartment of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Angélica Hernández-ArriagaLivestock Microbial Ecology Department, Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.
Carolin Victoria SchneiderDepartment of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Wilhelm SjölandDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden.
Antonio MolinaroDepartment of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden.
Michael TraunerDivision of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Christian TrautweinDepartment of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Amélia Camarinha-SilvaLivestock Microbial Ecology Department, Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.
Ina BergheimDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
Kai Markus SchneiderDepartment of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary fiber enrichment may modulate intestinal microbiota and positively impact metabolic dysfunction-associated steatotic liver disease (MASLD). This randomized, double-blind, placebo-controlled dual-center study evaluated the effects of dietary fiber (oat bran and spelt bran) on MASLD. After a 3-week Run-in phase during which dietary intake was assessed, 48 patients (CAP >280 dB, no fibrosis) were assigned to oat bran (4.5 g oat β-glucan, total fiber 11.7 g/day), spelt bran (11.7 g fiber/day), or placebo (2.1 g fiber/day) for 12 weeks. During the Run-in phase, dietary assessment alone significantly decreased BMI and liver enzymes (ALT, AST, γ-GT) while increasing microbiota diversity. Improvements were maintained in all three intervention groups. However, no significant changes were observed in hepatic steatosis (CAP), overall microbiota composition, and serum bile acid profiles. Dietary assessment alone improved MASLD biomarkers, with the fiber supplementation offering no additional benefit. This highlights the importance of dietary counseling in MASLD management. (clinical trials: NCT03897218).

Indexed as

clinical nutritionhuman metabolism

Identifiers

PMID41438070
PMCPMC12721201

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.