Evidence map›Paper›PMID 41438064›Full record

ArticleiScience2025

Yibo Zhu, Hongwei Liu, Fang Qu, Cuiling Wu, Yingzhi Wang, Juanjuan Yao, Ke Li, Zhonghui Wang, Shumin You, Lin Hua and 3 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yibo ZhuAccurate Biotechnology (Hunan) Co., Ltd, No. 1, Jinyang Road, Wangcheng District, Changsha 410006, China.
Hongwei LiuAccurate Biotechnology (Hunan) Co., Ltd, No. 1, Jinyang Road, Wangcheng District, Changsha 410006, China.
Fang QuAccurate Biotechnology (Hunan) Co., Ltd, No. 1, Jinyang Road, Wangcheng District, Changsha 410006, China.
Cuiling WuCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.
Yingzhi WangUniversity-Town Hospital of Chongqing Medical University, No. 55, Middle Road, University Town, Shapingba District, Chongqing 401331, China.
Juanjuan YaoDepartment of Clinical Laboratory, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157, Jinbi Road, Xishan District, Kunming 650032, China.
Ke LiCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.
Zhonghui WangCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.
Shumin YouCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.
Lin HuaCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.
Chunlei GeCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.
Hong YaoCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.
Tao LiCancer Biotherapy Center & Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, 519 Kunzhou Lu Xishan District, Kunming 650100, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moloney murine leukemia virus reverse transcriptase (MMLV RT) is an RNA-dependent DNA polymerase widely used in molecular diagnostics and gene editing. Its application is limited by poor thermal stability and inactivation induced by long-term storage. We combined multi-site mutagenesis with

Indexed as

Biochemistry applicationsEnzyme engineeringProteinProtein structure aspects

Identifiers

PMID41438064
PMCPMC12719197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.