ArticleiScience2025
THBS1 identificated as an endometriosis biomarker through evidence from single-cell and bulk transcriptomic profiling.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Expression Profiling of Immune-Related Genes in Different Samples from Patients with Endometriosis Revealed Upregulation ofInternational journal of molecular sciences · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis affects a substantial number of women of reproductive age, yet current diagnostic methods rely on invasive procedures. To address this limitation, we investigated THBS1 as a potential biomarker and regulator of disease progression. Integrating bulk and single-cell RNA sequencing data, we identified THBS1 as a gene enriched in ectopic endometrial tissues. Immunohistochemistry confirmed its elevated expression, while functional assays revealed that THBS1 promotes endometrial cell proliferation, migration, and invasion. In a subcutaneous xenograft model, THBS1 silencing by small interfering RNA suppressed ectopic lesion growth, demonstrating its functional relevance
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