Evidence map›Paper›PMID 41437948›Full record

ArticleResuscitation plus2026

Implementation of a regional extracorporeal membrane oxygenation program for out-of-hospital cardiac arrest: results of the prospective observational study.

Nichole Bosson, Juliana Tolles, Clayton Kazan, Stephen Sanko, Tiffany M Abramson, Marc Eckstein, David Eisner, Joel Geiderman, Walid Ghurabi, Vadim Gudzenko and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nichole BossonLos Angeles County EMS Agency, 10100 Pioneer Blvd, Santa Fe Springs, CA 90670, USA.
Juliana TollesHarbor-UCLA Medical Centre Department of Emergency Medicine and the Lundquist Institute for Research, 1000 W Carson Street, Torrance, CA 90502, USA.
Clayton KazanLos Angeles County Fire Department, 1320 N. Eastern Avenue, Los Angeles, CA 90063, USA.
Stephen SankoLos Angeles General Medical Centre, Department of Emergency Medicine, 2051 Marengo Street, Los Angeles, CA 90033, USA.
Tiffany M AbramsonLos Angeles General Medical Centre, Department of Emergency Medicine, 2051 Marengo Street, Los Angeles, CA 90033, USA.
Marc EcksteinLos Angeles General Medical Centre, Department of Emergency Medicine, 2051 Marengo Street, Los Angeles, CA 90033, USA.
David EisnerCulver City Fire Department, 9770 Culver Blvd, Culver City, CA 90232, USA.
Joel GeidermanCedars-Sinai Medical Centre, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Walid GhurabiDavid Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Vadim GudzenkoDavid Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Anil MehraLos Angeles General Medical Centre, Department of Emergency Medicine, 2051 Marengo Street, Los Angeles, CA 90033, USA.
Sam TorbatiCulver City Fire Department, 9770 Culver Blvd, Culver City, CA 90232, USA.
Atilla UnerDavid Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA.
Amir AbolhodaMemorialCare Heart and Vascular Institute (MHVI), Long Beach Medical Centre, 2801 Atlantic Ave, Long Beach, CA 90807, USA.
Marianne Gausche-HillLos Angeles County EMS Agency, 10100 Pioneer Blvd, Santa Fe Springs, CA 90670, USA.
David ShavelleMemorialCare Heart and Vascular Institute (MHVI), Long Beach Medical Centre, 2801 Atlantic Ave, Long Beach, CA 90807, USA.
Los Angeles County eCPR Program

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We implemented a multi-centre extracorporeal cardiopulmonary resuscitation (eCPR) program in a regional emergency medical services (EMS) system and assessed the time-to-cannulation, survival, and neurologic outcomes for patients routed by EMS to eCPR-capable centres. Methods: This was an observational study of patients with out-of-hospital cardiac arrest (OHCA) transported to eCPR-capable centres from July 2020 to September 2024. Patients were routed to an eCPR-capable centre if all applied: age 15-75, refractory/recurrent shockable arrest, a mechanical compression device (MCD) applied, and treatment by a participating EMS unit. Additional patients were routed on clinician judgment. Patients with traumatic arrest, do-not-resuscitate order, known terminal illness, baseline severe neurologic deficit, pregnancy, MCD contraindications, or estimated >30-min transport to an eCPR-capable centre were not routed. The outcomes were survival to hospital discharge (SHD) and neurologic status at discharge. We conducted a logistic regression with inverse-probability weighting to evaluate the association between eCPR and patient outcomes. Results: There were 233 patients routed for eCPR. Median age was 58 years (IQR 48-65), 51 (22 %) were female. Fifty-eight (27 %) were cannulated for eCPR; median time from arrest to cannulation was 66 min (IQR 58-78). Both for all routed patients and among those cannulated, SHD was 27 % and SHD with cerebral performance category (CPC) 1 or 2 was 21 %. In the regression analysis, eCPR was not associated with improved outcomes. Conclusion: In this regional eCPR program, survival among patients refractory to conventional therapy and treated with eCPR was 27%.

Indexed as

Emergency medical servicesExtracorporeal cardiopulmonary resuscitationOut-of-hospital cardiac arrest

Identifiers

PMID41437948
PMCPMC12721277

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.