ArticleTherapeutic advances in medical oncology2025
Trastuzumab and pertuzumab plus carboplatin-based neoadjuvant therapy for HER2-positive breast cancer: a prospective cohort study with integrated genomic and transcriptomic biomarker analysis.
Article in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Tumor mutations predict HER2-targeted therapy resistance in primary HER2-positive breast cancer.NPJ breast cancer · 2026Article
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Abstract
Background: Neoadjuvant trastuzumab and pertuzumab combined with carboplatin and taxane (TCbHP) is the standard treatment for human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, limited clinical data and efficacy biomarkers for TCbHP have been reported in Chinese HER2-positive breast cancer patients. Objectives: This study aimed to observe the pathological complete response (pCR) rate in the cohort, with an exploratory analysis of efficacy-related biomarkers in a subset of patients. Design: This was a prospective, observational, non-interventional cohort study. Methods: Patients with HER2-positive breast cancer treated with TCbHP neoadjuvant therapy were prospectively collected. Exploratory genomic and transcriptomic biomarker analyses were performed in a subset of patients with available baseline tumour specimens retrospectively collected. Results: A total of 252 patients with a median age of 48 years were enrolled. Patients with stage III were 69.4% (175/252), and clinical N3 patients accounted for 24.6% (62/252). Patients with hormone receptor (HR) positive were 62.7% (158/252). Total pCR rate was 55.2% (139/252). HR-negative and HR-positive rates were 72.3% (68/94) and 44.9% (71/158), respectively. Among neoadjuvant taxanes, including paclitaxel, docetaxel, and nab-paclitaxel, the pCR rates were 50.0% (57/114), 50.0% (41/82), and 73.2% (41/56), respectively. Multivariate logistic regression analyses showed that HR negativity, receiving nab-paclitaxel, HER2 3+, and cT1-2 were independent predictive factors of high pCR. Genomic and transcriptomic analyses were performed on baseline tumour specimens from 40 patients. Genomic analysis revealed lower pCR rates in patients with Conclusion: Neoadjuvant trastuzumab and pertuzumab with carboplatin-based chemotherapy is the recommended regimen for Chinese patients with HER2-positive breast cancer, and nab-paclitaxel may be an optimal alternative taxane for TCbHP regimens.
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