Evidence map›Paper›PMID 41437842›Full record

ArticleGut microbes2026

Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.

Lena K Siewert, Kristina Berve, Elisabeth Pössnecker, Julia Dyckow, Amel Zulji, Ryan Baumann, Aida Munoz-Blazquez, Gurumoorthy Krishnamoorthy, David Schreiner, Sharon Sagan and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Female-enrichedbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lena K SiewertDepartments of Neurology, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.
Kristina BerveDepartments of Neurology, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.
Elisabeth PössneckerDepartments of Neurology, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0002-6271-2404
Julia DyckowDepartment of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Amel ZuljiDepartment of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Ryan BaumannDepartment of Neurology & Weill Institute for Neurosciences, University of California, San Francisco, US.
Aida Munoz-BlazquezDepartments of Neurology, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.
Gurumoorthy KrishnamoorthyCenter of Neurology, Department of Neuroimmunology, University Hospital and University Bonn, Bonn, Germany.
David SchreinerDepartments of Neurology, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.
Sharon SaganDepartment of Neurology & Weill Institute for Neurosciences, University of California, San Francisco, US.
Charlotte NelsonDepartment of Neurology & Weill Institute for Neurosciences, University of California, San Francisco, US.
Joseph J SabatinoDepartment of Neurology & Weill Institute for Neurosciences, University of California, San Francisco, US.
Kazuki NagashimaDepartment of Bioengineering, Stanford University, Stanford, CA, US.
Médéric DiardBiozentrum, University of Basel, Basel, Switzerland.
Andrew J MacphersonDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Stephanie C Ganal-VonarburgDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Michael A FischbachDepartment of Bioengineering, Stanford University, Stanford, CA, US.
Scott S ZamvilDepartment of Neurology & Weill Institute for Neurosciences, University of California, San Francisco, US.
Lucas SchirmerDepartment of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sergio E BaranziniDepartment of Neurology & Weill Institute for Neurosciences, University of California, San Francisco, US.
Anne-Katrin PröbstelDepartments of Neurology, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.

Funding

Decode and design T cell induction by a complex gut microbial communityK99AI173524 · NIAID · STANFORD UNIVERSITY · PI NAGASHIMA, KAZUKI · 2023 to 2024
$261k
NIAID NIH HHS K99 AI173524
6 · The paper itself

Abstract

Microbiome-based therapies are promising new treatment avenues. While global alterations in microbiota composition have been shown in multiple sclerosis, whether and how gut microbiota influence autoimmune responses in an antigen-specific manner is unclear. Here, we genetically engineered gut bacteria to express a brain antigen and dissect their pathogenic potential in a murine model of autoimmune neuroinflammation. Colonization with bacteria expressing myelin - but not ovalbumin-peptide exacerbates an encephalitogenic immune response in the gut by activating antigen-specific T cells as well as B cells leading to accelerated neuroinflammatory disease. These results demonstrate how antigen-specific microbial modulation can influence autoimmunity, providing insight for development of therapeutic strategies targeting specific bacterial taxa for treatment of MS and other autoimmune diseases.

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalGastrointestinal MicrobiomeNeuroinflammatory DiseasesAnimalsAntigensAutoimmunityBacteriaB-LymphocytesDisease Models, AnimalFemaleMiceMice, Inbred C57BLMultiple SclerosisT-LymphocytesAntigensMicrobiomemucosal immunologymultiple sclerosisneuroinflammation

Identifiers

PMID41437842
PMCPMC12962552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.