Evidence map›Paper›PMID 41437837›Full record

ArticleChronic respiratory disease

Clinical implications of frailty in hospitalized patients with pulmonary arterial hypertension.

Ashira Lokhandwala, Ali Salman Al-Timimi, Tania Da Silva, Sahar Nourouzpour, H S Jeffrey Man, Marc de Perrot, Kirsten Wentlandt, Nadia Sharif, Lianne G Singer, John Granton and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frailty in Pulmonary Arterial Hypertension: A Cohort Study.Annals of the American Thoracic Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ashira LokhandwalaToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Ali Salman Al-TimimiToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Tania Da SilvaToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Sahar NourouzpourToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
H S Jeffrey ManToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Marc de PerrotToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Kirsten WentlandtDivision of Palliative Care, University Health Network, Toronto, ON, Canada.
Nadia SharifMOH, Hera General Hospital, Mecca, Saudi Arabia.ORCID 0000-0001-9961-515X
Lianne G SingerTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
John GrantonTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Dmitry RozenbergTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-8786-9152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectivesFrailty is associated with increased morbidity and mortality in chronic lung disease, but its prognosis has not been evaluated in pulmonary arterial hypertension (PAH). This study aimed to assess: (1) impact of frailty on hospital length of stay (LOS) and health-care utilization in PAH; (2) association of frailty with 1-year post-discharge outcomes.MethodsRetrospective, single-centered cohort study of consecutive PAH patients admitted non-electively (January 2009-December 2018), predominantly for right heart failure (57%). Frailty was defined as ≥ 0.25 using a cumulative deficits frailty index. Disease characteristics, hospital factors, and mortality were compared using univariate analysis and multivariable regression, adjusting for age and sex.Results44/96 (46%) PAH patients were frail. Frailty was associated with older age, greater comorbidities, and lower six-minute walk distance pre-admission (

Indexed as

FrailtyLength of StayPatient Acceptance of Health CarePulmonary Arterial HypertensionAgedAged, 80 and overAge FactorsComorbidityFemaleHospitalizationHospital MortalityHumansMaleMiddle AgedPrognosisRetrospective Studiesfrailtyhospitalizationpulmonary hypertension

Identifiers

PMID41437837
PMCPMC12743802

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.