Trial reportActas espanolas de psiquiatria2025
Effects of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Pulmonary Lobectomy: A Randomised, Single-Blind Controlled Clinical Trial.
Trial report in Actas espanolas de psiquiatria, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Clinical research progress of esketamine in perioperative neuroprotection: from mechanisms to therapeutic neuroprotection.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElderly patients undergoing pulmonary lobectomy with incision are at a high risk for postoperative cognitive dysfunction (POCD). Intraoperative esketamine may offer potential neuroprotective benefits. This study aimed to evaluate the efficacy of intraoperative esketamine in reducing the incidence of POCD in elderly patients undergoing pulmonary lobectomy with incision.
methodsIn this single-blind, controlled clinical trial, patients (aged 65-75 years) undergoing conventional pulmonary lobectomy were randomly allocated to receive esketamine (0.3 mg/kg/h) or remifentanil (0.1-0.2 µg/kg/min) during surgery. Cognitive function was assessed using the mini-mental state examination (MMSE) and negative emotional scores were recorded at baseline and multiple postoperative time points. Intraoperative and postoperative parameters, including heart rate (HR) and mean arterial pressure (MAP), pain scores and adverse events, were recorded. Blood samples were collected to measure amyloid-beta (Aβ) and microtubule-associated protein tau (tau) concentrations.
resultsNo significant difference was found in the incidence of postoperative delirium between the two groups, but the esketamine group exhibited a significantly lower incidence of POCD on days 1 and 3 postoperatively than the control group. The esketamine group also had significantly higher serum Aβ42/40 levels and significantly lower tau levels on day 1 postoperatively. At the end of surgery, the HR, MAP and pain visual analogue scale score of the control group were significantly higher than those of the esketamine group. No significant differences were observed in terms of adverse events between the two groups.
conclusionIntraoperative administration of esketamine (0.3 mg/kg/h) was associated with a lower incidence of POCD and more stable hemodynamic indicators in elderly patients undergoing thoracic surgery, without increasing adverse events. The application of esketamine indicates a possible benefit with a favourable safety profile in reducing postoperative cognitive decline in this population.
trial registrationChinese Clinical Trial Registry, ChiCTR2200065266.
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