Evidence map›Paper›PMID 41437520›Full record

ArticleHuman brain mapping2025

Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex.

Maggie K Pecsok, Golia Shafiei, Ally Atkins, Monica E Calkins, Ruben C Gur, Ravi Prakash Reddy Nanga, Ravinder Reddy, Melanie A Matyi, Jacquelyn Stifelman, Heather Robinson and 8 more

Abstract read
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maggie K PecsokBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-6806-5423
Golia ShafieiPenn Lifespan Informatics & Neuroimaging Center, Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ally AtkinsBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Monica E CalkinsBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ruben C GurBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ravi Prakash Reddy NangaCenter for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ravinder ReddyCenter for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Melanie A MatyiDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Jacquelyn StifelmanBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Heather RobinsonBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Erica B BallerPenn Lifespan Informatics & Neuroimaging Center, Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Endeavor (PennSIVE), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kosha RuparelBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kristin A LinnPenn Statistics in Imaging and Visualization Endeavor (PennSIVE), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daniel H WolfBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Theodore D SatterthwaitePenn Lifespan Informatics & Neuroimaging Center, Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7072-9399
Corey T McMillanDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
David RoalfBrain Behavior Lab, Neurodevelopment and Psychosis Section, Penn-Chop Lifespan Brain Institute, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Funding

Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JASON H KARLAWISH · 2021 to 2026
$24.8M
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
Harmonization of Multi-Site Neuroimaging Data from Complex Study DesignsR01MH123550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2025
$4.0M
Ultra-high field GluCEST MRI and MRS in youth at risk for psychosisR01MH120174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2024
$3.8M
Evolution of Psychosis in Youth: Multimodal Risk and Resilience MarkersR01MH119219 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E, GUR, RUBEN C. · 2019 to 2023
$3.8M
Olfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndromeR01MH119185 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2019 to 2024
$3.5M
Imaging of glutamatergic system changes in Alzheimer's disease in vivoR01AG063869 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2020 to 2024
$3.0M
Advanced Statistical Analytics of MRI in MSR01NS112274 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2024
$2.8M
Novel Imaging Biomarkers of Lipid and Ketone Metabolism in Alzheimer's DiseaseRF1AG087306 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2024 to 2024
$2.1M
Depression as a disease of network disruption: learning from multiple sclerosisK23MH133118 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Erica Berlin Baller · 2023 to 2026
$780k
Glutamate Chemical Exchange Saturation Transfer (GluCEST) Imaging in Cognitive AgingR56AG066656 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2020
$533k
NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG063869NIA NIH HHS R56 AG066656NIA NIH HHS RF1 AG087306NIBIB NIH HHS P41 EB029460NIBIB NIH HHS P41EB029460NIH HHS R01AG063869NIH HHS RF1AG087306NIMH NIH HHS F30 MH136690NIMH NIH HHS F30MH136690NIMH NIH HHS K23 MH133118NIMH NIH HHS R01 MH112847NIMH NIH HHS R01MH112847NIMH NIH HHS R01 MH119185NIMH NIH HHS R01MH119185NIMH NIH HHS R01 MH119219NIMH NIH HHS R01 MH120174NIMH NIH HHS R01MH120174NIMH NIH HHS R01 MH123550NIMH NIH HHS R01MH123550NIMH NIH HHS R01NS112274NIMH NIH HHS R56AG066656NINDS NIH HHS R01 NS112274
6 · The paper itself

Abstract

Glutamate-weighted Chemical Exchange Saturation Transfer (GluCEST) captures in vivo glutamate (Glu) levels with high spatial resolution and has been used to assess glutamatergic function in healthy and clinical populations. While GluCEST is well-validated against proton magnetic resonance spectroscopy (

Indexed as

Cerebral CortexGlutamic AcidMagnetic Resonance ImagingPsychotic DisordersReceptor, Metabotropic Glutamate 5Receptors, GABA-AReceptors, NeurotransmitterReceptors, N-Methyl-D-AspartateAdolescentAdultFemaleHumansMalePositron-Emission TomographyYoung AdultGlutamic AcidGRM5 protein, humanReceptor, Metabotropic Glutamate 5Receptors, GABA-AReceptors, NeurotransmitterReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41437520
PMCPMC12728121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.