Evidence map›Paper›PMID 41437515›Full record

ArticleVirulence2026

Inhibitors of GapN-dependent NADPH supply as potential lead compounds for novel therapeutics against

Isabell Schütt, Philip Einwohlt, Anna-Maria Wandinger, Jonathan Teuffel, Regina Wirsing, Ben H Hlawatschke, Hanna L Fehlauer, Sebastian Bothe, Nicole Bader, Emanuele Monaci and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Isabell SchüttInstitute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Center, Rostock, Germany.ORCID 0009-0002-3996-7166
Philip EinwohltInstitute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Center, Rostock, Germany.
Anna-Maria WandingerRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Jonathan TeuffelMolecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
Regina WirsingRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Ben H HlawatschkeInstitute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Center, Rostock, Germany.
Hanna L FehlauerInstitute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Center, Rostock, Germany.
Sebastian BotheRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Nicole BaderRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Emanuele MonaciMolecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
Bernd KreikemeyerInstitute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0001-9527-5098
Hermann SchindelinRudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Rebecca C WadeMolecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
Tomas FiedlerInstitute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0001-6717-1865

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections with

Indexed as

Anti-Bacterial AgentsBacterial ProteinsEnzyme InhibitorsGlyceraldehyde-3-Phosphate DehydrogenasesNADPStreptococcus pyogenesHumansMicrobial Sensitivity TestsMolecular Docking SimulationStreptococcal InfectionsAnti-Bacterial AgentsBacterial ProteinsEnzyme InhibitorsGlyceraldehyde-3-Phosphate DehydrogenasesNADPantimicrobialscomputational dockingdrug targetGapNglyoxal bisulfiteStreptococcus pyogenes

Identifiers

PMID41437515
PMCPMC12758328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.