Evidence map›Paper›PMID 41437446›Full record

ReviewThe American journal of nursing2026

Sickle Cell Disease: Treatment Options of the Past, Present, and Future.

Charleen T Jacobs-McFarlane, Angela Liu

Abstract readReview
In one paragraph

Review in The American journal of nursing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Charleen T Jacobs-McFarlaneCharleen T. Jacobs-McFarlane is an NP at Mount Sinai Hospital, and Angela Liu is a hematologist at the Icahn School of Medicine at Mount Sinai, both in New York City. Jacobs-McFarlane has reported receiving ongoing funding from the National Heart, Lung, and Blood Institute, National Institutes of Health, and past funding from Pfizer. Contact author: Charleen T. Jacobs-McFarlane, charleen.jacobs-mcfarlane@mountsinai.org . The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.
Angela Liu

Funding

Mount Sinai Clinician Scientist Training Program in Emergency Care ResearchT32HL160513 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Lynne D. Richardson · 2022 to 2026
$2.2M
NHLBI NIH HHS T32 HL160513
6 · The paper itself

Abstract

abstractSickle cell disease (SCD) is an inherited red blood cell disorder that affects an estimated 70,000 to 100,000 people in the United States, most of whom are of African descent. SCD causes acute and chronic pain and widespread end-organ damage, resulting in acute and chronic complications, high morbidity, and early death. Advances in research and treatment have improved patient outcomes for people living with SCD. Over the past 10 years, several new medications and curative therapies have been approved by the U.S. Food and Drug Administration for people with SCD, and more medications are in the pipeline. This review includes historical perspectives, current treatment options, and future directions for this population. With the ongoing rapid changes in SCD care, nurses are well positioned to play a role in patient education, research, advocacy, and the implementation of these emerging therapies to advance the care of those affected by SCD.

Indexed as

Anemia, Sickle CellAntisickling AgentsHumansHydroxyureaUnited StatesAntisickling AgentsHydroxyureaaccess to careclinical updatescurative therapiessickle cell disease

Identifiers

PMID41437446
PMCPMC13274735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.