ArticleJournal of orthopaedic surgery and research2025
The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute periprosthetic joint infection.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute periprosthetic joint infection (PJI) is a serious complication after total knee and hip replacement, with varying success rates in its management using debridement, antibiotics, and implant retention (DAIR). We hypothesize that the application of post-operative continuous negative pressure therapy (CNPT) can improve the success rate of DAIR in the treatment of acute knee and hip PJI.
methodsIn this retrospective study from October 2018 to December 2022, 62 patients diagnosed with acute PJI were divided into two groups: 24 patients treated with DAIR and CNPT, and 38 patients treated with DAIR alone. The groups were comparable in terms of patient characteristics, organism profile, and clinical findings. The primary outcome was treatment failure based on the Delphi consensus criteria for 1-year follow up. The statistical analysis involved univariate and multivariate regression.
resultsAfter a year of follow-up, the CNPT group had a significantly lower treatment failure rate (25%) compared to the control group (55.3%, p = 0.019). After controlling the confounding factors, the use of CNPT remained as a significant factor with a lower OR (adjusted OR: 0.13; 95% CI 0.02-0.86, p = 0.034), indicating its potential effectiveness in improving DAIR outcomes.
conclusionThe study suggests that CNPT could substantially enhance the success rate of DAIR in treating acute PJI. This intervention may represent a significant advancement in post-operative care, potentially reducing the failure rate of DAIR treatment and improving patient outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.