Evidence map›Paper›PMID 41437384›Full record

ArticleParasites & vectors2025

Susceptibility of Lutzomyia longipalpis (Lutz & Neiva, 1912) to Fludora FusionPM, a combination of clothianidin and deltamethrin: field and laboratory bioassays.

Greicielly Barbosa Santos Silva, Josiane Valadão Lopes, Grasielle Caldas D' Ávila Pessoa, Leticia Cavalari Pinheiro, João Paulo Dos Santos, Fabiana Oliveira Lara-Silva, Nadja Biondine Marriel, Liléia Gonçalves Diotaiuti, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias

Abstract read
In one paragraph

Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Greicielly Barbosa Santos SilvaLaboratório de Leishmanioses, Instituto René Rachou (FIOCRUZ Minas), Av. Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-009, Brazil.
Josiane Valadão LopesLaboratório de Leishmanioses, Instituto René Rachou (FIOCRUZ Minas), Av. Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-009, Brazil.
Grasielle Caldas D' Ávila PessoaDepartamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos, 6627, Belo Horizonte, MG, CEP 31270-901, Brazil.
Leticia Cavalari PinheiroNúcleo de Estudos em Saúde Pública e Envelhecimento (NESPE), Instituto René Rachou (FIOCRUZ Minas), Av. Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-009, Brazil.
João Paulo Dos SantosUnidade de Controle de Zoonoses, Secretaria Municipal de Saúde, Rua Bom Jesus s/n, Jaboticatubas, MG, CEP 35830-000, Brazil.
Fabiana Oliveira Lara-SilvaLaboratório de Leishmanioses, Instituto René Rachou (FIOCRUZ Minas), Av. Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-009, Brazil.
Nadja Biondine MarrielLaboratório de Leishmanioses, Instituto René Rachou (FIOCRUZ Minas), Av. Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-009, Brazil.
Liléia Gonçalves DiotaiutiLaboratório de Referência em Triatomíneos e Epidemiologia da Doença de Chagas, Instituto René Rachou (FIOCRUZ Minas), Av. Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-009, Brazil.
Consuelo Latorre Fortes-DiasDiretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias (FUNED), Rua Conde Pereira Carneiro 80, Belo Horizonte, MG, CEP 30550-010, Brazil.
Edelberto Santos DiasLaboratório de Leishmanioses, Instituto René Rachou (FIOCRUZ Minas), Av. Augusto de Lima 1715, Belo Horizonte, MG, CEP 30190-009, Brazil. edelberto.dias@fiocruz.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsecticides remain a cornerstone in the control of vector-borne diseases. In Brazil, Alfatek 200SC-a pyrethroid (alphacypermethrin)-is recommended for controlling phlebotomine sand flies, the vectors of leishmaniases. For mosquitoes such as Aedes aegypti, a combination of deltamethrin and clothianidin (Fludora FusionPM) is endorsed. This study evaluated the efficacy of Fludora FusionPM against phlebotomine sand flies.

methodsLaboratory bioassays were conducted using Fludora FusionPM-impregnated filter papers stored either at room temperature (25 ± 2 °C) or under cold conditions (3 ± 1 °C). In field trials, painted (PS) or unpainted (US) masonry-plastered walls in selected households were treated with the insecticide. Alfatek 200SC was used as a reference, following the same procedures. Lutzomyia longipalpis females (n = 25 per replicate, in triplicate) were exposed for 60 min using the cone test. Mortality was assessed 1 h and 24 h postexposure and quarterly over 1 year. Structured questionnaires were administered to the community endemic agent (CEA) responsible for spraying and to household residents to document perceived adverse effects.

resultsIn the laboratory, the residual activity expressed by average mortality rates over 1 year of paper impregnation was of 97.6% for Fludora FusionPM) and 91.7% for Alfatek 200SC). In the field, 1-year average mortality rates were 97.3% for Fludora FusionPM and 94.6% for Alfatek 200SC for PS. On US walls, Fludora

conclusionsFludora FusionPM was highly toxic to Lu. longipalpis and outperformed Alfatek 200SC under field conditions, particularly on unpainted masonry-plastered walls. Combining insecticides with complementary modes of action may enhance rotational strategies, reduce costs and resistance risk, and optimize control of multiple vector-borne diseases simultaneously.

Indexed as

GuanidinesInsecticidesNeonicotinoidsNitrilesPsychodidaePyrethrinsThiazolesAnimalsBiological AssayBrazilFemaleInsect VectorsclothianidindecamethrinGuanidinesInsecticidesNeonicotinoidsNitrilesPyrethrinsThiazolesChemical controlInsecticideLeishmaniasisNeonicotinoidPhlebotomine sand flyPyrethroid

Identifiers

PMID41437384
PMCPMC12849672

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.