Evidence map›Paper›PMID 41437344›Full record

SynthesisBMC endocrine disorders2025

The impact of vitamin D supplementation on anti-Müllerian hormone levels: a systematic review and meta-analysis.

Parmis Mirzaei, Ghazaleh Eslamian, Mohammad Hassan Sohouli, Zeinab S Tadayoni

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Parmis MirzaeiDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ghazaleh EslamianDepartment of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, No 7, Hafezi St., Farahzadi Blvd, P.O.Box: 19395-4741, Tehran, 1981619573, Iran. gh.eslamian@sbmu.ac.ir.
Mohammad Hassan SohouliDepartment of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, No 7, Hafezi St., Farahzadi Blvd, P.O.Box: 19395-4741, Tehran, 1981619573, Iran.
Zeinab S TadayoniDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe possible anti-Mullerian hormone (AMH)-reduction impact of vitamin D supplementation has been assessed in a number of interventional investigations. The outcomes are still incongruous, however. This research sought to thoroughly examine the effects of vitamin D supplementation on AMH in order to have a better understanding of them.

methodsUsing standard keywords, the Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase databases were searched to find all controlled trials examining the levels of AMH after vitamin D treatment. For the best result estimate, random-effects model analysis produced 95% confidence intervals and a pooled weighted mean difference.

resultsThis article includes sixteen research with a total of 484 participants. Vitamin D supplementation did not significantly affect AMH levels in single-arm (pooled WMD of -0.22 ng/ml; 95% CI -0.68 to 0.23; P = 0.333) or randomized clinical trial (pooled WMD of -0.07 ng/ml; 95% CI -1.01 to 0.87; P = 0.887) studies, according to pooled results from the random-effects model. Vitamin D during the intervention < 8 weeks and in individuals with low baseline levels of vitamin D serum induces a higher drop in AMH levels, according to the findings of subgroup analysis.

conclusionsDespite the inconclusive and conflicting evidence on the relationship between vitamin D supplementation and AMH levels in women, it is evident that vitamin D may play a role in mitigating the negative impact of AMH on follicular development and granulosa cell differentiation. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Anti-Mullerian HormoneDietary SupplementsVitamin DVitaminsFemaleHumansAnti-Mullerian HormoneVitamin DVitaminsAMHMeta-analysisPCOSVitamin DWomen

Identifiers

PMID41437344
PMCPMC12837038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.