Evidence map›Paper›PMID 41437336›Full record

ReviewBMC pregnancy and childbirth2025

The importance of early veno-arterial extracorporeal membrane oxygenation in the management of amniotic fluid embolism complicated by cardiac arrest: a case report and literature review.

Junyou Su, Jing Luo, Hongfei Chen, Junru Tong, Yan Chen, Lingling Huang, Xiaoting Huang, Shi Liao, Yan Huang, Li Deng

Abstract readCase ReportsReview
In one paragraph

Review in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junyou Su *Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Jing Luo *Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Hongfei ChenDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Junru TongDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Yan ChenDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Lingling HuangDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Xiaoting HuangDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Shi LiaoDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Yan HuangDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China. huangyan@sr.gxmu.edu.cn.
Li DengDepartment of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China. dengli@gxmu.edu.cn.

Funding

Guangxi Medical and Health Key Cultivation Discipline Construction Project 2022050Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation 2024GXNSFBA010162
6 · The paper itself

Abstract

backgroundAmniotic fluid embolism (AFE) with cardiac arrest is an obstetric emergency with an exceedingly high maternal mortality. Early application of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may provide essential cardiopulmonary support, but its clinical value warrants further investigation. CASE REPORT: This report describes the successful management of a 36-year-old parturient with advanced maternal age who sustained sudden cardiac arrest due to AFE during the second stage of labor. Immediately following arrest, the patient received high-quality CPR and achieved return of spontaneous circulation (ROSC) within four minutes. A multidisciplinary team initiated early VA-ECMO support with an anticoagulation-free strategy post-ROSC, acting as a critical bridging therapy to cardiopulmonary recovery. Although total hysterectomy was subsequently performed for refractory severe postpartum hemorrhage, the patient ultimately achieved complete recovery and was discharged without sequelae, including thromboembolic complications or severe neurological deficits.

conclusionsThis case demonstrates the feasibility and potential utility of early VA-ECMO as a resuscitative therapy for AFE-induced cardiac arrest. Its successful application in this setting justifies further evaluation of ECPR in peripartum emergencies.

Indexed as

Embolism, Amniotic FluidExtracorporeal Membrane OxygenationHeart ArrestAdultCardiopulmonary ResuscitationFemaleHumansPregnancyAmniotic fluid embolismCardiac arrestExtracorporeal membrane oxygenationVeno-arterial

Identifiers

PMID41437336
PMCPMC12836970

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.