ArticleBMC pulmonary medicine2025
Modulatory roles of the vagus nerve and nicotine in bleomycin-induced pulmonary fibrosis in rats.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026Review
- Inter-Organ Communication in Pulmonary Fibrosis: Systemic Modifiers of a Lung-Centered Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary fibrosis is a chronic and progressive lung disease with limited therapeutic options. This study aimed to investigate the roles of the vagus nerve and nicotine in bleomycin-induced pulmonary fibrosis in rats.
methodsMale Sprague-Dawley rats were randomly assigned to five groups: Sham (SHAM; intratracheal [I.T.] saline), bleomycin (BLM; 2 mg/kg, I.T.), bleomycin with right cervical vagotomy (BLVR), bleomycin with nicotine (0.5 mg/kg/day, intraperitoneal [I.P.]) (BLNC), and bleomycin with vagotomy plus nicotine (BLVN).
resultsTwenty-four hours after bleomycin or saline administration, total white blood cell (WBC) counts and the neutrophil-to-lymphocyte ratio (NLR) increased in all groups, with the BLVR group exhibiting significantly higher values than the BLM, BLNC, and BLVN groups. On day 14, NLR in the BLVR group and WBC counts in the BLM and BLVR groups remained elevated. Lung malondialdehyde levels were higher in the BLM and BLVR groups compared with the BLNC and BLVN groups. During mechanical ventilation, peak expiratory pressures were higher in the BLM, BLVR, and BLNC groups than in the SHAM group, whereas the BLVN group showed values comparable to the SHAM group. Lung compliance was lowest in the BLVR group but was preserved in the BLVN group. Histopathological examination confirmed reduced lung injury in the BLVN group compared with the BLM and BLVR groups.
conclusionsThese findings highlight the anti-inflammatory role of the vagus nerve and suggest that nicotine-particularly in combination with vagotomy-may confer protective effects against early-stage pulmonary fibrosis by mitigating inflammation, oxidative stress, and pulmonary dysfunction.
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