ArticleBMC ophthalmology2025
Evaluation of systemic inflammatory biomarkers associated with high-density lipoprotein in keratoconus patients: a retrospective case-control study.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo evaluate systemic inflammatory markers including the monocyte to high density lipoprotein cholesterol (HDL) ratio (MHR), neutrophil to HDL ratio (NHR), lymphocyte to HDL ratio (LHR), neutrophil to lymphocyte ratio (NLR), platelet to HDL ratio (PHR) in patients with keratoconus (KC). Correlations between these systemic markers and corneal topographic parameters were also investigated.
methodsRetrospective analysis of peripheral blood sample results in patients with KC (n: 103) were performed. Mean MHR, NHR, LHR, NLR, and PHR were calculated in KC patients, and age and sex matched healthy controls (n:99). Corneal topography markers were also evaluated and correlations with systemic inflammatory markers were investigated.
resultsThe mean PHR was significantly higher in KC group compared to control group (p = 0.004). Optimal PHR cut-off value for KC was calculated as 4807 with 74.8% sensitivity and 45.5% specificity. No significant correlation was found between corneal topograhy parameters and systemic inflammatory markers.
conclusionsThe mean PHR value was found to be higher in patients with keratoconus and no correlation was found between corneal topography findings and systemic inflammatory markers. This study is the first to explore HDL associated systemic inflammatory markers.
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