Interplay between TGF-β signaling and long non-coding RNAs in digestive system cancers: mechanisms and biological implications.

Penghui Li, Di Huang, Xinyu Gu

Abstract readReview

In one paragraph

Review in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Penghui LiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, 471000, Henan, China.

Di HuangDepartment of Child Health Care, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Xinyu GuDepartment of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, No. 24 Jinghua Road, Jianxi District, Luoyang, 471000, Henan, China. hkdguxy@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction between the transforming growth factor beta (TGFβ) signaling pathway and long non-coding RNAs (lncRNAs) has been known to contribute to the progression and metastasis of digestive system cancers. Dysregulated expression of lncRNAs associated with the TGFβ-Smad signaling pathway is correlated with several clinical features in digestive system cancers. These lncRNAs regulate multiple biological functions, including epithelial-to-mesenchymal transition (EMT), tumor growth, and immune responses. They interact with key molecules in the TGFβ-Smad pathway to influence gene transcription and cellular behavior. Alterations in the expression of these lncRNAs can serve as valuable biomarkers for early detection and prognosis. Targeting the lncRNA-TGFβ axis offers a novel approach to cancer treatment. This review summarizes the interactions between the TGFβ signaling pathway and lncRNAs in digestive system cancers, highlighting their potential in diagnosis, prognosis, and therapy.

Indexed as

Digestive System NeoplasmsRNA, Long NoncodingSignal TransductionTransforming Growth Factor betaBiomarkers, TumorEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisPrognosisSmad ProteinsBiomarkers, TumorRNA, Long NoncodingSmad ProteinsTransforming Growth Factor betaBiomarkersClinical featuresDigestive system cancersLong non-coding RNAsTGFβ signaling

Identifiers

PMID41437175

DOI10.1007/s13577-025-01341-5

PMCPMC12727859

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.