ArticleCommunications chemistry2025
Chemical and photoinduced interstrand crosslinking of oligo DNA duplexes containing 2'-deoxythioguanosines.
Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Singlet oxygen-mediated photocatalytic generation of abasic sites in DNA.Communications chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Interstrand crosslinked nucleic acids offer diverse applications, including stabilizing DNA nanostructures in nanotechnology, enhancing miRNA inhibition in therapeutics, and studying enzyme activity in biochemistry. In this study, we present a new crosslinking design strategy that incorporates two 2'-deoxythioguanosine residues at noncomplementary yet strategically proximal positions within an oligo DNA duplex, promoting efficient disulfide crosslinking under chemical oxidation conditions. Additionally, this approach enables a photoinduced crosslinking reaction using 365 nm UV light, further facilitating the formation of disulfide crosslinked duplex. Our results demonstrate that the proximity of reactive thiocarbonyl groups of 2'-deoxythioguanosines incorporated within the duplex favors disulfide bond formation. Herein, we report the design strategy, crosslinking reaction results, and characterization of the crosslinked product. Furthermore, we introduce a new photoinduced disulfide crosslinking reaction and elucidate its mechanism.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.