SynthesisSystematic reviews2025
Prevalence of sickle cell disease and sickle cell traits among children and adolescents in Nigeria: a systematic review and meta-analysis.
Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Contemporary global burden of sickle cell anaemia under-5 and under-20: A systematic review and meta-analysis.British journal of haematology · 2026Pooled it
- Prevalence of sickle cell disease and sickle cell traits among children and adolescents in Nigeria: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- A machine-learning capillary electrophoresis-based pattern to identify suspected sickle cell trait and α-thalassemia co-inheritance.Advances in laboratory medicine · 2026Article
- Top ten surgical tricks-penile prosthesis with corporal fibrosis.International journal of impotence research · 2026Review
- Comparative analysis of serum vitamin D and haematological parameters among paediatric sickle cell and non-sickle cell patients at a teaching hospital in Accra, Ghana: a case-control study.BMC pediatrics · 2026Article
- Integrated Newborn Screening in Nigeria: The Way Forward, A Workshop Report.International journal of neonatal screening · 2026Article
- Quantitative Volumetric Analysis of the Brain Using Magnetic Resonance Imaging in Sickle Cell Anaemia.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSickle cell disease (SCD) is one of the most common genetic disorders in the world, with Nigeria believed to have the highest burden. Despite the high burden in the country, the true prevalence of SCD and its main driver-the sickle cell trait (SCT)-is unknown, which is important for planning and resource allocation. Hence, we conducted a systematic review and meta-analysis of the prevalence of SCD, SCT, and associated factors in Nigerian children and adolescents.
methodsUsing the PRISMA guidelines [ID: CRD42024556354], we systematically search the following major databases: AJOL, Google Scholar, PubMed, EMBASE, Cochrane Library, Scopus, and Web of Science collections from January 1950 to October 2024 on Nigerian children and adolescents with SCD and/or SCT. The quality of the studies was assessed using the Newcastle-Ottawa Scale adapted for cross-sectional studies. We performed a cumulative meta-analysis to estimate the pooled prevalence and associated factors for SCD and SCT.
resultsThirty studies, comprising 211,938 participants, were included in the final analysis after stepwise screening. The pooled prevalences of SCD and SCT were 4.0% (95% CI 3.0 to 6.0, I
conclusionThe pooled prevalence of SCD and SCT among children and adolescents was high, with the highest burden occurring in the northwestern geopolitical zone in Nigeria. In addition, there was no relationship between sex, socioeconomic class, and prevalence of SCD. SYSTEMATIC REVIEW REGISTRATION: PROSPERO ID: CRD42024556354.
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