ArticleAntimicrobial resistance and infection control2025
Evaluation of IR BIOTYPER
Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
backgroundTraditional typing methods, such as pulsed-field gel electrophoresis (PFGE), multi-locus sequence typing (MLST) and Whole genome sequencing (WGS) have limitations in terms of labor intensity, cost, and delayed results. This study evaluates Fourier transform infrared spectroscopy (FTIR), particularly IR Biotyper
methodsThe research involves retrospective analysis of 72 carbapenem-resistant strains of E. cloacae complex, assessing the IR Biotyper's efficacy, discriminatory power, and concordance with PFGE and WGS. Clustering concordance was evaluated using Simpson's index of diversity (SID) and adjusted Rand index (ARI). Methodology was tested in a real-world outbreak investigation compared with WGS.
resultsThe results underscore the benefits of IRBT, which include rapid turnaround times under 3 h, cost-effectiveness, and operational simplicity. IR Biotyper
conclusionsOur study proposes FTIR as a powerful tool for typing of E. cloacae complex, specifically IR Biotyper
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