Evidence map›Paper›PMID 41437120›Full record

ReviewTranslational neurodegeneration2025

Microfluidic platform for understanding Parkinson's disease and α-synuclein conformation.

Tregub Pavel, Zembatov Georgy, Namiot Eugenia, Kolotyeva Natalia, Yurchenko Stanislav, Illarioshkin Sergey, Salmina Alla

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational neurodegeneration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tregub PavelRussian Center of Neurology and Neurosciences, Moscow, Russia, 125367. pfiza_asmu@mail.ru.ORCID http://orcid.org/0000-0002-3650-6121
Zembatov GeorgyRussian Center of Neurology and Neurosciences, Moscow, Russia, 125367.ORCID http://orcid.org/0000-0002-0825-8909
Namiot EugeniaRussian Center of Neurology and Neurosciences, Moscow, Russia, 125367.ORCID http://orcid.org/0000-0003-3725-6360
Kolotyeva NataliaRussian Center of Neurology and Neurosciences, Moscow, Russia, 125367.ORCID http://orcid.org/0000-0002-7853-6222
Yurchenko StanislavBauman Moscow State Technical University, Moscow, Russia, 105005.ORCID http://orcid.org/0000-0001-6821-904X
Illarioshkin SergeyRussian Center of Neurology and Neurosciences, Moscow, Russia, 125367.ORCID http://orcid.org/0000-0002-2704-6282
Salmina AllaRussian Center of Neurology and Neurosciences, Moscow, Russia, 125367.ORCID http://orcid.org/0000-0003-4012-6348

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2024-638
6 · The paper itself

Abstract

Microfluidic systems are an innovative engineering solution that is increasingly being used in a wide range of scientific fields. These systems use fluids in microchannels (1 to 300 microns) to analyze extremely small volumes of sample and reagent, allowing precise delivery and mixing while maintaining accurate results. Parkinson's disease (PD) poses significant diagnostic challenges, with early detection being critical to improved treatment outcomes. A key pathological feature of PD is the presence of Lewy bodies composed of α-synuclein (αSyn) fibrils. Recent research has shown that αSyn oligomers can be toxic and contribute to neuronal loss. Therefore, microfluidics offers a promising approach for the diagnosis of different stages of αSyn pathology. This review comprehensively analyzes the application of microfluidics in single-cell analysis and protein aggregation studies. We discuss the concept of lab-on-a-chip analysis and examine different substrates for αSyn detection, citing relevant studies and expected protein concentrations and their correlations with disease progression and severity.

Indexed as

alpha-SynucleinLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesMicrofluidicsParkinson DiseaseAnimalsHumansProtein Conformationalpha-SynucleinAberrant proteinLab-on-a-chipMicrofluidicOrgan-on-a-chipParkinson’s diseaseα-Synuclein

Identifiers

PMID41437120
PMCPMC12729760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.