Evidence map›Paper›PMID 41437097›Full record

ArticleJournal of translational medicine2025

AI-assisted preoperative surgical planning for dental implant.

Fanxuan Chen, Haoman Chen, Darong Hai, Yilei Yang, Peng Xu, Dongren Yang, Ruoyun Wang, Zixuan Bi, Chang Yuan, Yijun Wang and 8 more

Abstract read
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Fanxuan Chen *Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Haoman Chen *Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China.
Darong Hai *School of Nursing, Wenzhou Medical University, Wenzhou, 325000, China.
Yilei Yang *The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, 325001, China.
Peng Xu *School of Electronics and Information Engineering, University of Science and Technology Liaoning, Anshan, 114051, China.
Dongren YangThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, 325001, China.
Ruoyun WangThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, 325001, China.
Zixuan BiThe Second Clinical Medical College of Wenzhou Medical University, Wenzhou, 325000, China.
Chang YuanThe Second Clinical Medical College of Wenzhou Medical University, Wenzhou, 325000, China.
Yijun WangThe Second Clinical Medical College of Wenzhou Medical University, Wenzhou, 325000, China.
Chufan RenThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, 325001, China.
Li ZengThe Second Clinical Medical College of Wenzhou Medical University, Wenzhou, 325000, China.
Zefei MoSchool of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China.
Yan ZhangDepartment of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Jingye PanDepartment of Big Data in Health Science, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. panjingye@wzhospital.ac.cn.
Gen YangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China. gen.yang@pku.edu.cn.
Qi ZhaoSchool of Computer Science and Software Engineering, University of Science and Technology Liaoning, Anshan, 114051, China. zhaoqi@lnu.edu.cn.ORCID 0000-0001-9713-1864
Mei YangDepartment of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. yangmei1@wmu.edu.cn.

Funding

Fundamental Research Funds for the Liaoning Universities LJ212410146026Key Clinical Specialty Program of the Zhejiang Province of Critical Care Medicine Y2022National Natural Science Foundation of China 12375334National Natural Science Foundation of China 82272204Pioneer and Leading Goose R&D Program of Zhejiang 2023C03084Science and Technology Plan Project of Liaoning Province 2025-MSLH-351Zhejiang Provincial Medical and Health Science and Technology Plan 2024KY1262Zhejiang Provincial Medical and Health Science and Technology Plan 2025KY1000Zhejiang Provincial Natural Science Foundation of China LY21H050006
6 · The paper itself

Abstract

backgroundAn accurate preoperative assessment of alveolar bone morphology is essential to the success of dental implant surgery. Although Cone Beam Computed Tomography (CBCT) provides high-resolution volumetric imaging for this purpose, interpreting it requires substantial expertise and remains inherently subjective. Integrating artificial intelligence (AI), specifically three-dimensional convolutional neural networks (3D-CNNs), could automate and standardize CBCT interpretation. However, there has been no systematic development of AI-driven preoperative tools capable of objectively predicting the necessity of adjunctive procedures, such as guided bone regeneration or maxillary sinus elevation.

methodsWe retrospectively collect 285 CBCT datasets from a single institution from patients undergoing dental implant surgery. Then, we construct a 3D-CNN–based deep learning model to automatically predict the need for adjunctive surgical intervention prior to implant placement. To optimize the model’s performance, we design a four-stage optimization framework that incorporates multimodal data augmentation, learning rate decay scheduling, optimizer selection, and convolutional channel configuration. We comprehensively evaluate model performance using accuracy (ACC), area under the receiver operating characteristic curve (AUC), and F1-score across training, validation, and test sets. We employ Grad-CAM visualization to reveal spatial attention patterns and apply LASSO regression to extract key latent features from the model’s fully connected layers. These features are then used to create a quantitative nomogram to improve clinical interpretability.

resultsThe optimized 3D-CNN achieves an accuracy of 0.81, an AUC of 0.79, and an F1-score of 0.82 on the validation and test sets, demonstrating strong discriminative and generalizability capabilities. Grad-CAM heatmaps shows that the model focuses on the edentulous ridge and the adjacent maxillary sinus regions, which are areas that align with expert clinical reasoning. LASSO regression identifies 14 high-contribution features for constructing an interpretable clinical nomogram (AUC = 0.855). Decision curve analysis indicates a positive net clinical benefit across multiple threshold ranges.

conclusionsThis study presents a 3D-CNN-based CBCT interpretation model that can objectively predict the need for bone augmentation procedures before implant surgery. Integrating multimodal data augmentation and standardized Hounsfield unit (HU) normalization significantly improve the model’s robustness and generalization. By combining deep learning with clinical decision-making processes, this study provides an interpretable, quantitative artificial intelligence (AI) framework for preoperative implant assessment. As the current model was developed, optimized, and tested on a single-center dataset, prospective multicenter external validation across diverse patient populations, varied CBCT acquisition protocols, and different clinical practice settings is essential to establish its generalizability and clinical utility before widespread deployment. This framework offers a feasible paradigm for future intelligent, standardized surgical planning in dental implantology.

Indexed as

Artificial IntelligenceDental ImplantsPreoperative CareSurgery, Computer-AssistedCone-Beam Computed TomographyConvolutional Neural NetworksHumansImaging, Three-DimensionalROC CurveDental Implants3D-CNNBone augmentationCBCTDental implantologyModel interpretability

Identifiers

PMID41437097
PMCPMC12838012

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.