ArticleEuropean journal of medical research2025
The association of frailty and mechanical power with hospital mortality in critically ill patients: a retrospective study based on the MIMIC-IV and eICU database.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
backgroundFrailty, characterized by diminished physiological reserve, and high mechanical power are well-established risk factors for mortality in critically ill patients. However, the potential synergistic impact of these two factors on clinical outcomes remains insufficiently explored.
methodsBaseline data from critically ill patients were extracted from the MIMIC-IV and eICU-CRD databases. Frailty was evaluated using the Laboratory-based Frailty Index (FI-Lab), and mechanical ventilation intensity was quantified by mechanical power (MP). Generalized linear mixed models (GLMMs) and logistic regression analyses were employed to assess the associations between FI-Lab, MP, their interaction, and hospital mortality.
resultsA total of 17,881 critically ill patients were included-13,740 from MIMIC-IV and 4,141 from eICU. Both MP (MIMIC-IV: OR 1.126; 95% CI 1.093-1.160; eICU: OR 1.165; 95% CI 1.094-1.241) and FI-Lab (MIMIC-IV: OR 1.169; 95% CI 1.158-1.179; eICU: OR 1.240; 95% CI 1.215-1.266) showed significant associations with hospital mortality in both cohorts. The effect estimates for MP were consistent across databases (I
conclusionsFI-Lab and mechanical power are independently associated with hospital mortality, and their interaction further amplifies the risk. These findings suggest that integrating frailty assessment with mechanical power monitoring may enhance risk stratification in critically ill patients.
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