Evidence map›Paper›PMID 41437069›Full record

ArticleHead & face medicine2025

Prognostic value of different immunohistopathological patterns and Ki67 proliferation index for Merkel cell carcinoma.

Katharina Theresa Obermeier, Wenko Smolka, Maximilian Kollmuss, Sabina Noreen Wuersching, Ina Dewenter, Philipp Poxleiter, Sven Otto, Yoana Malenova, Florian Fegg, Paris Liokatis

Abstract read
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In one paragraph

Article in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katharina Theresa ObermeierDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany.
Wenko SmolkaDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany.
Maximilian KollmussDepartment of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Goethestrasse 70, Munich, 80336, Germany.
Sabina Noreen WuerschingDepartment of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Goethestrasse 70, Munich, 80336, Germany.
Ina DewenterDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany. ina.dewenter@campus.lmu.de.
Philipp PoxleiterDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany.
Sven OttoDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany.
Yoana MalenovaDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany.
Florian FeggDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany.
Paris LiokatisDepartment of Oral and Maxillofacial Surgery and Facial Plastic Surgery, University Hospital, LMU Munich, Lindwurmstrasse 2a, Munich, 80337, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin tumor, which preferentially appears in the head and neck area. Overall 5-year survival is about 66–70% in patients with non-metastasized tumors and reduces to 42% in cases with regional metastases, and down to 18% in case of distant metastases. The Ki67- index is one of the most important biological markers in neuroendocrine tumors and is recently known as a prognostic marker in pancreatic neuroendocrine neoplasms. This study aims to evaluate the prognostic role of Ki67 in Merkel cell carcinoma. A cut-off value for Ki67 index was calculated using Youden’s index. Overall, 16 patients were included in this retrospective study. The best matching cutoff value for our data was calculated at 77.5%. Ki67 turned out to be > 85% in patients with local recurrence of MCC and > 90% with lymph node metastases. A Ki67-index of 77.5% stratified the patients in our cohort most efficiently. A safety margin higher than 1 cm should be aimed.

Indexed as

Carcinoma, Merkel CellKi-67 AntigenSkin NeoplasmsAgedAged, 80 and overBiomarkers, TumorFemaleHumansImmunohistochemistryLymphatic MetastasisMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNon-Melanoma Skin NeoplasmsPrognosisBiomarkers, TumorKi-67 AntigenKi67-indexLymphatic metastasisMerkel cell carcinomaNeuroendocrine skin tumorsPrognostic marker

Identifiers

PMID41437069
PMCPMC12849675

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.