Evidence map›Paper›PMID 41437063›Full record

ArticleJournal of nanobiotechnology2025

Flexibility-powered Pickering emulsion enhances mucus permeability to alleviate ulcerative colitis.

Jiali Lv, Chen Cheng, Xinran Liu, Jinhua Song, Daxiang Li, Yijun Wang, Yiqun Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiali Lv *State Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Food and Nutrition, Anhui Agricultural University, Hefei, 230036, China.
Chen Cheng *Institute of Clinical Immunology, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230032, China.
Xinran LiuState Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Food and Nutrition, Anhui Agricultural University, Hefei, 230036, China.
Jinhua SongState Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Food and Nutrition, Anhui Agricultural University, Hefei, 230036, China.
Daxiang LiState Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Food and Nutrition, Anhui Agricultural University, Hefei, 230036, China.
Yijun WangState Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Food and Nutrition, Anhui Agricultural University, Hefei, 230036, China.
Yiqun DuState Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Food and Nutrition, Anhui Agricultural University, Hefei, 230036, China. duyiqun@ahau.edu.cn.

Funding

Anhui Agricultural University rc352212National Natural Science Foundation of China 32402031Natural Science Foundation of Anhui Province 2408085QC095State Key Laboratory of Tea Plant Biology and Utilization SKLTOF20230103The Earmarked Found for CARS CARS-19
6 · The paper itself

Abstract

The physicochemical properties of oral drug delivery carriers significantly influence their interactions with the intestinal barrier, which, in turn, affect their in vivo fate and therapeutic efficacy. As a delivery system with a hierarchical structure and high stability, Pickering emulsions have demonstrated significant advantages in enhancing the bioavailability of encapsulated bioactive compounds. However, the specific role of their inherent flexibility in modulating interactions with the intestinal barrier and influencing delivery efficiency remains poorly understood. In this study, a flexible Pickering emulsion (FPPE) stabilized by chitosan nanoparticles was developed for encapsulating epigallocatechin gallate, aiming to investigate the role and underlying mechanism of its flexible structure in mucus penetration, cellular uptake, and biodistribution in the intestinal tract. Upon reaching the intestinal tissue, FPPE exhibited deformable adaptation, facilitating efficient mucus permeation, prolonged gastrointestinal retention, and enhanced drug absorption. Moreover, FPPE enhanced macrophage uptake and mitochondrial membrane potential, reduced reactive oxygen species scavenging, and triggered macrophage reprogramming. Compared to rigid chitosan microspheres, FPPE more effectively alleviated intestinal inflammation and promoted intestinal barrier repair in a dextran sulfate sodium-induced acute colitis mouse model. This study reveals how Pickering emulsion flexibility facilitates intestinal mucus delivery, guiding their future design and application.

Indexed as

Colitis, UlcerativeMucusAnimalsCatechinChitosanDextran SulfateDisease Models, AnimalDrug CarriersDrug Delivery SystemsEmulsionsIntestinal MucosaMaleMiceMice, Inbred C57BLNanoparticlesPermeabilityCatechinChitosanDextran SulfateDrug CarriersEmulsionsepigallocatechin gallateChitosanEGCGFlexibility deformationOral deliveryPickering emulsionUlcerative colitis

Identifiers

PMID41437063
PMCPMC12729323

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.