ArticleBMC endocrine disorders2025
Association between the novel dietary index for gut microbiota, biomarkers of hashimoto's thyroiditis and metabolic parameters among women of reproductive age.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging evidence highlights the role of gut microbiota in autoimmune diseases, including Hashimoto's thyroiditis (HT). Diet is a key modulator of gut microbial composition. This study investigated the association between a novel Dietary Index for Gut Microbiota (DIGM) and thyroid-related biomarkers among women with HT.
methodsIn this cross-sectional study, 162 women with clinically confirmed HT were enrolled. Dietary intake was assessed using a validated food frequency questionnaire. The DIGM score was constructed based on intake of foods known to influence gut microbial health, with higher scores indicating greater adherence to a microbiota-supportive diet. Anthropometric parameters and serum levels of thyroid hormones, thyroid autoantibodies, lipid profile, and oxidative stress markers were measured. Participants were categorized into tertiles based on DIGM score, and comparisons across groups were made using ANOVA and general linear models, adjusting for potential confounders.
resultsParticipants in the highest DIGM tertile had significantly lower serum anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibody levels (P < 0.05), lower triglyceride concentrations (p = 0.017), and reduced waist-to-hip ratio (p = 0.030) compared to those in the lowest tertile. No significant differences were observed in TSH, T3, T4, anti-Tg, TAC, or MDA levels across DIGM categories.
conclusionHigher adherence to a microbiota-supportive dietary pattern, as reflected by the DIGM score, was associated with favorable immune and metabolic profiles in women with HT. Due to the cross-sectional design of the study, causal relationships cannot be inferred. Further longitudinal or intervention studies are needed to elucidate causality and to suggest dietary modulation of gut microbiota as a non-pharmacological approach to support management of autoimmune thyroid disease. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.