SynthesisBMC pulmonary medicine2025
Prevalence and associated factors of post-tuberculosis lung disease in Sub-Saharan Africa: a systematic review and meta-analysis.
Synthesis in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of pulmonary rehabilitation on lung function and quality of life in pulmonary tuberculosis survivors with post-tuberculosis lung disease: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Prevalence of abnormal spirometry and correlates of lung function decline among a population in rural Uganda.Journal of global health · 2026Article
- Post-Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management.MedComm · 2026Review
- Lung Cancer Risk Factors Beyond Smoking in Ethiopia: A Multicenter Matched Case-Control Study.Cancers · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-tuberculosis lung disease (PTLD) is a major public health challenge in sub-Saharan Africa (SSA), where the burden of tuberculosis (TB) remains high. Only a few studies have reported the global burden of PTLD, and the associated factors of PTLD have been understudied. This systematic review and meta-analysis aimed to estimate the pooled prevalence and associated factors of PTLD in SSA.
methodsThis study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines for systematic review and meta-analysis. We included studies reporting the prevalence and associated factors of PTLD among individuals with a history of pulmonary TB in SSA. A comprehensive literature search was conducted via PubMed, Embase, Google Scholar, and African Journal Online databases from February 25, 2025, to March 20, 2025. The pooled prevalence of PTLD was estimated using a random-effects model. Due to the lack of reports on adjusted odds ratios (aORs), the associated factors were analyzed using crude odds ratios (ORs).
resultsA total of 21 studies, consisting of 4,463 participants, were included. The overall pooled prevalence of PTLD in SSA was 43.26% (95% CI: 34.17%-52.34%). The key Factors significantly associated with PTLD included: female sex (OR: 1.57, 95% CI: 1.16, 2.11), smoking (OR: 1.64, 95% CI: 1.09, 2.46), Presence of cough (OR: 1.73, 95% CI: 1.03, 2.9) and fibrotic pattern (OR:3.94 (95% CI: 1.96, 7.92).
conclusionNearly half of prior TB patients in SSA develop PTLD. Being female, smoking, fibrosis, and post-treatment cough were key factors associated with PTLD. To effectively manage PTLD in SSA, it is important to implement targeted interventions for high-risk groups, strengthen screening and chronic care services, enhance healthcare system capacity, ensure equity in health resources and integrate PTLD management into national TB control programs.
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