ArticleBMC infectious diseases2025
Integrating chest radiography-based TB screening and preventive treatment for household contacts in Pakistan: a pilot study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPakistan ranks fifth among countries with the highest tuberculosis (TB) incidence worldwide, yet only approximately 70% of TB patients receive treatment. The World Health Organisation (WHO) recommends active TB case finding and TB preventive treatment (TPT) for household contacts (HHCs) following exclusion of active TB disease. We piloted the integration of WHO-recommended chest X-ray (CXR) screening and TPT for HHCs, with data collection via PREVENT-TB app.
methodsA mixed-method pilot study was conducted in 19 healthcare facilities in Hafizabad and Nankana Sahib districts of Punjab, Pakistan, from December 2021 to September 2023. It aimed to assess the acceptability and feasibility of a CXR based TB screening among HHCs, the initiation of TPT, and the feasibility of using a mobile application to document the intervention and its completeness. Descriptive statistics and binary logistic regression were used to analyse quantitative data. Thematic analysis was used to analyse semi-structured interviews with programme staff, healthcare providers and patients. Digital and paper-based data collection approaches were compared.
resultsAmong 694 index TB patients, 2817 HHCs were identified, of whom 1421 (50%) underwent CXR and symptom screening. A total of 118 (8%) screened HHCs had TB symptoms and/or CXR abnormalities and 5 (4%) were diagnosed with TB. Of the 1416 HHCs eligible for TPT, 957 (68%) initiated TPT, and among these 903 (94%) completed their treatment. The most common reason for refusal of screening and TPT was perceived lack of need by HHCs. Digital data collection was found to satisfactorily support both implementation and monitoring.
conclusionsIntegrating CXR screening and TPT into routine primary healthcare with digital monitoring are feasible.
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