ArticleBMC cardiovascular disorders2025
Longitudinal strain in left ventricular non-compaction: insights derived from two-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging strain.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLeft ventricular non-compaction (LVNC) is a heterogeneous cardiomyopathic phenotype, often associated with impaired systolic function. Advanced imaging modalities such as cardiac magnetic resonance (CMR) and speckle-tracking echocardiography (STE) allow detailed assessment of myocardial structure and deformation, yet the patterns of global and segmental longitudinal strain (LS) in LVNC remain insufficiently defined. This study aimed to evaluate global and regional LS in patients with CMR-confirmed LVNC using two-dimensional STE and CMR feature-tracking, and to assess the consistency between these two modalities.
methodsThirty-five adults with CMR-confirmed LVNC referred to the Cardiovascular Centers of Shiraz University of Medical Sciences (March 2022-December 2023) were retrospectively analyzed. All patients underwent transthoracic echocardiography with LS assessment by 2D-STE, and CMR-derived LS was obtained when image quality permitted. Demographic, clinical, and imaging parameters were recorded. Non-parametric statistical tests were used with correction for multiple comparisons.
resultsThe mean age was 43.3 ± 14.3 years; 71.4% were men. CMR most frequently identified non-compaction in the lateral (91.4%) and apical (51.4%) segments. Global LS was reduced in all patients. STE demonstrated significantly greater LS impairment in apical segments compared with basal segments (P < 0.001; mid vs. basal P = 0.004; apical vs. mid P = 0.017). Patients with a higher number of non-compacted segments exhibited greater LS reduction. In the subset with analyzable CMR strain data, LS values in the apical and mid-ventricular regions were comparable between CMR and STE (P > 0.05), whereas basal strain values differed significantly between modalities (P = 0.003).
conclusionPatients with CMR-confirmed LVNC demonstrated reduced global LS and a consistent pattern of more pronounced apical strain impairment. STE and CMR showed reasonable concordance in mid-apical regions, supporting the complementary role of deformation imaging in the evaluation of LVNC. Incorporating LS into routine assessment may improve detection of functional impairment. Further studies are needed to determine the optimal strain-based approach and clarify its relationship with underlying anatomical abnormalities.
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