ArticleBMC anesthesiology2025
Sufentanil preconditioning reduces hepatic ischemia-reperfusion injury in rats by regulating ferroptosis through ATF3.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury.World journal of transplantation · 2026Review
- Sufentanil attenuates LPS-induced acute lung injury by suppressing ferroptosis and maintaining GPX4 protein abundance.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo examine the correlation between the therapeutic efficacy of sufentanil preconditioning on hepatic ischemia-reperfusion injury (HIRI)-induced ferroptosis and the activation of activating transcription factor 3 (ATF3), as well as to elucidate the underlying mechanisms involved.
methodsEighteen Sprague-Dawley (SD) male rats were randomly assigned to three groups: a sham operation group, an ischemia-reperfusion injury group, and a sufentanil pretreatment group. Serum transaminase levels, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were measured to assess liver function. Liver injury was evaluated using hematoxylin and eosin staining. Ferroptosis was assessed by measuring iron content, glutathione peroxidase 4 (GPX4) expression levels, and mitochondrial morphological changes in hepatocytes. The relationship between the protective effects of sufentanil and ATF3 was investigated through immunohistochemistry, Western blotting, and quantitative real-time polymerase chain reaction (qRT-PCR).
resultsSufentanil pretreatment was found to ameliorate liver tissue damage, attenuate the inflammatory response, and mitigate ferroptosis in the context of HIRI. Furthermore, Sufentanil enhanced the expression levels of ATF3 while concurrently reducing iron content within liver tissue.
conclusionSufentanil preconditioning may mitigate ferroptosis associated with HIRI through the upregulation of ATF3 expression. This protective mechanism may be linked to a concomitant reduction in iron levels.
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