Evidence map›Paper›PMID 41436890›Full record

Trial reportInternational journal of obesity (2005)2026

Long-term change in body composition following intentional weight loss and its effect on physical function.

Kacey Chae, Xiaoyan Leng, Rebecca H Neiberg, George A Bray, Karen C Johnson, James O Hill, John M Jakicic, Ariana M Chao, Kristen M Beavers, Henry J Pownall and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kacey ChaeDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xiaoyan LengDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Rebecca H NeibergDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
George A BrayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0001-9945-8772
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-3493-4077
James O HillDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
John M JakicicDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.ORCID http://orcid.org/0000-0001-6800-9368
Ariana M ChaoJohns Hopkins School of Nursing, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5633-8973
Kristen M BeaversDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Henry J PownallDepartment of Cardiology, Houston Methodist Research Institute and Baylor College of Medicine, Houston, TX, USA.
Stephen B KritchevskyDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Denise K HoustonDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. denise.houston@wfusm.edu.
Look AHEAD Movement and Memory Ancillary Study Research Group

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
Intentional weight reduction and physical and cognitive functionR01AG033087 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HOUSTON, DENISE KATHRYN · 2009 to 2013
$4.0M
NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG033087
6 · The paper itself

Abstract

BACKGROUND/

objectivesA concern with intentional weight loss among middle-aged and older adults with obesity and type 2 diabetes mellitus (T2DM) is the loss of lean mass, which may lead to declining physical function. However, the association between changes in body composition with intentional weight loss and physical function over the long-term is unknown. Thus, we examined the association between changes in body composition and physical function 8 years following an intensive lifestyle intervention (ILI). SUBJECTS/

methodsWe conducted a secondary analysis of participants at the Baton Rouge site within the Look AHEAD study. Participants (n = 220) were middle-aged and older adults with overweight/obesity and T2DM randomized to an ILI or diabetes support and education (DSE). Body composition was measured by dual-energy X-ray absorptiometry at baseline and Year 8. Physical performance (expanded Short Physical Performance Battery [SPPB

resultsPercent change (mean ± SD) from baseline in weight, fat and lean mass over 8 years were -4.0 ± 7.3%, 0.2 ± 12.5% and -6.5 ± 5.3% in ILI and -3.0 ± 9.7%, 1.2 ± 17.1% and -5.8 ± 6.6% in DSE, respectively. ILI had better SPPB

conclusionsAlthough the overall intervention effect on physical function was positive, increases in fat mass were associated with poorer physical performance while lean mass loss was associated with weaker strength 8 years post-randomization. Findings highlight the importance of minimizing fat mass gain/regain and loss of lean mass during intentional weight loss.

Indexed as

Body CompositionDiabetes Mellitus, Type 2ObesityPhysical Functional PerformanceWeight LossAgedFemaleHumansMaleMiddle Aged

Identifiers

PMID41436890
PMCPMC13056564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.