ArticleAesthetic plastic surgery2026
Comparative Analysis of Collagen Induction in Sprague Dawley Rat Model Using Absorbable Threads for Facial Lifting and Rejuvenation.
Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Response to: Can 8-week Male Rat Data Guide Female Facial Thread Lifts?Aesthetic plastic surgery · 2026Article
- Letter Regarding Needle-Free PDLLA Rejuvenation-The Missing Link Between Treatment Session Frequency and Cost-Effectiveness Optimization.Aesthetic plastic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThis study aimed to evaluate the efficacy and biocompatibility of various absorbable threads from Hans BioMed for facial lifting in a Sprague Dawley rat model, focusing on collagen production, inflammatory responses, and overall skin remodeling.
methodsSix types of absorbable threads, PCL, PDO, PDLLA, PLCL, and two P4HB variants (55 and 90% elongation) from Hans BioMed, were analyzed using histological, immunohistochemical, and molecular methods for observation, including 1, 2, 4, and 8 weeks post-thread insertion. Total 140 rats were used with 20 rats for each thread group, in which five rats for each time point.
resultsFirstly, inflammatory markers, including TNF-α and IL-6, peaked at 1 week and subsided significantly by 8 weeks, confirming the safety profile of all threads. The overall results demonstrated that all threads induced collagen formation and reduced inflammation over time. Notably, collagen 1 levels in all testing groups steadily increased from 2 to 8 weeks, complemented by reduced metalloproteinase expression, indicating preserved collagen stability, observed in Western Blotting. Additionally, RT-PCR highlighted increased expression of collagen-related genes and elevated TGF-β and α-SMA levels, suggesting enhanced skin remodeling capabilities.
conclusionAll tested absorbable threads promoted collagen formation and showed minimal response to inflammation over time. The findings provide a foundation for developing advanced thread-lifting products, offering improved skin elasticity, firmness, and collagen synthesis outcomes. NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://link.springer.com/journal/00266 .
Indexed as
Identifiers
41436887What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.