Evidence map›Paper›PMID 41436829›Full record

ArticleScientific reports2025

SLC11A1 can activate TGF-β1 signaling pathway to resist ferroptosis in colorectal cancer.

DongQiang Yang, LianMei Zhao, Ping Shi, Jianfeng Zhang, Guang Yang, Bo Shi, Hongqing Ma, Baokun Li, Feifei Wang, Guiying Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

DongQiang YangDepartment of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
LianMei ZhaoScientific Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Ping ShiOtorhinolaryngology Head and Neck Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Jianfeng ZhangThe Second Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Guang YangDepartment of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Bo ShiDepartment of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Hongqing MaThe Second Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Baokun LiThe Second Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Feifei WangThe Second Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Guiying WangThe Second Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. wangguiying@hebmu.edu.cn.

Funding

Hebei province central government to guide the local science and technology special projects 236Z7757GHebei Province Natural Innovation Group project H2022206355National Natural Science Foundation of China 82272909
6 · The paper itself

Abstract

High expression of Solute Carrier Family 11 Member 1(SLC11A1) leads to a poor prognosis in patients with CRC, while the specific role of SLC11A1 in CRC remains unreported. Therefore, this study mainly addressed the preliminary mechanism and specific role of SLC11A1 in CRC. The results showed that six subsequent genes were successfully screened by the line database, and the abnormal expression of SLC11A1 was the most obvious in colorectal cancer patients. Following phenotypic experiments demonstrated that SLC11A1 promoted proliferation, invasion and migration of colorectal cancer cells. SLC11A1 Is also able to downregulate Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL 4), Cyclooxygenase-2 (COX2), NADPH Oxidase 1 (NOX1) and upregulate the expression levels of Hypoxia-Inducible Factor 1 (FIH1), Glutathione Peroxidase 1 (GPX1) protein, inhibit the expression levels of MDA and Fe

Indexed as

Cation Transport ProteinsColorectal NeoplasmsFerroptosisSignal TransductionTransforming Growth Factor beta1Cell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansCation Transport ProteinsTGFB1 protein, humanTransforming Growth Factor beta1Colorectal cancerFerroptosisInvasion and metastasisSolute carrier family 11 member 1Transforming growth factor beta 1 signaling pathway

Identifiers

PMID41436829
PMCPMC12827322

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.