Evidence map›Paper›PMID 41436740›Full record

ArticleScientific reports2025

The sobol sensitivity analysis of the pressure, stresses, and displacement arising from poroelastic modelling of hard mechanical systems.

Hadi Asghari, Laura Miller, Raimondo Penta, Andrey Melnikov, Christos Spitas, Jose Merodio

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Hadi AsghariDepartment of Mathematics, School of Sciences and Humanities, Nazarbayev University, Kabanbay Batyr 53, 010000, Astana, Kazakhstan.
Laura MillerDepartment of Mathematics and Statistics, University of Strathclyde, Livingstone Tower, 26 Richmond Street, G1 1XH, Glasgow, UK.
Raimondo PentaSchool of Mathematics and Statistics, University of Glasgow, G12 8QQ, Glasgow, UK. Raimondo.Penta@Glasgow.ac.uk.
Andrey MelnikovDepartment of Mathematics, School of Sciences and Humanities, Nazarbayev University, Kabanbay Batyr 53, 010000, Astana, Kazakhstan.
Christos SpitasDepartment of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, Ningbo, China.
Jose MerodioDepartamento de Matematica Aplicada a las TIC, Universidad Politecnica de Madrid, Madrid, Spain.

Funding

Engineering and Physical Sciences Research Council EP/S030875/1Nazarbayev University 211123CRP1616
6 · The paper itself

Abstract

We perform a sensitivity analysis to investigate the influence of material input parameters on the pressure, stresses, and displacement of an isotropic porous solid cylinder representing hard mechanical systems such as the bone. We model the system using the governing equations of Biot's poroelasticity in cylindrical polar coordinates, where the solutions are found by enforcing radial boundary conditions. The sensitivity analysis is carried out on the solutions for the pressure, stress components and displacement using ranges of the investigated parameters representative of the bone. Our study finds that the time [Formula: see text] has the highest influence on the pressure, the stress components and displacements. We find that the Poisson ratio ν plays a greater role than shear μ in the pressure response, and the shear μ counts more than the other parameters in the radial and circumferential stresses. There are key joint interactions between the Biot's coefficient α and the Poisson ratio ν, the non-dimensionalised radius [Formula: see text] of the bone, and the Biot's modulus M when investigating interstitial pressure, which is a key value in bone remodelling and fracture healing. This study paves the way to a deeper understanding of the interplay of all the parameters that are necessary to capture the true behaviour of hard mechanical systems such as the bone and its potential remodelling.

Indexed as

Biot’s poroelasticityHard mechanical systemsSobol statistical method

Identifiers

PMID41436740
PMCPMC12728179

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