Evidence map›Paper›PMID 41436734›Full record

ArticleNature communications2025

In vivo electrochemical reduction-induced reconfiguration of Prussian blue for metal counterion-free potassium removal in hyperkalemia.

Yuge Wu, Liang Xiang, Xin Zhao, Tianzhi Liu, Yao Xiao, Xiaolin Cui, Futao Tang, Zhen Liu, Ju Zeng, Shiyi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuge Wu *School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.ORCID http://orcid.org/0009-0004-1508-6131
Liang Xiang *School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.ORCID http://orcid.org/0000-0002-5656-2083
Xin ZhaoSuzhou Intelligem Pharmaceutical Technology Co. Ltd, Suzhou, PR China.
Tianzhi LiuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.ORCID http://orcid.org/0009-0003-1189-859X
Yao XiaoSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.
Xiaolin CuiSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.
Futao TangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.
Zhen LiuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.ORCID http://orcid.org/0000-0002-5710-050X
Ju ZengSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China.
Shiyi ZhangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China. zhangshiyi@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-9375-5992

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22171184National Natural Science Foundation of China (National Science Foundation of China) T2550061Shanghai Municipal Education Commission ZXWH1082101
6 · The paper itself

Abstract

Hyperkalemia, a life-threatening metabolic disorder, persists as unmet medical need since current first-line pharmacotherapy-ion-exchange potassium binders-inevitably release metal counterions (e.g., sodium) that paradoxically aggravate metabolic comorbidities. Here, we present a paradigm-shifting in vivo reduction-induced ion-selective adsorption (IRISA) strategy, utilizing Prussian Blue and Vitamin C for metal counterion-free potassium removal. IRISA leverages VC to trigger structural remodeling of PB through Fe reduction, inducing spin-state transitions and lattice reconfiguration that create K

Indexed as

FerrocyanidesHyperkalemiaPotassiumAdsorptionAnimalsAscorbic AcidDisease Models, AnimalElectrochemical TechniquesMaleOxidation-ReductionRatsSodiumAscorbic Acidferric ferrocyanideFerrocyanidesPotassiumSodium

Identifiers

PMID41436734
PMCPMC12847950

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.