Active Antibiotic Treatment Improves ART Outcomes in TPOAb-Positive Chronic Endometritis Patients: A Retrospective Study.

Mingmei Lin, Ruiqi Wang, Yue Wang, Yueqi Leng, Zeyang Lin, Rong Li

Abstract read

In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Mingmei Lin *Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Ruiqi Wang *Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Yue Wang *Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Yueqi LengCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Zeyang LinCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Rong LiCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. roseli001@sina.com.ORCID 0000-0003-0305-5579

Funding

Clinical Key Incubation Project A of Peking University Third Hospital BYSYZD2023022National Natural Science Foundation of China 81925013National Natural Science Foundation of China 82288102the Frontiers Medical Center, Tianfu Jincheng Laboratory Foundation Project No. TFJC2023010001the Key Projects of Yunnan Province Science and Technology Department 202302AA310044the National Key R&D Program of China 2021YFC2700601the National Key R&D Program of China 2022YFC2702500

6 · The paper itself

Abstract

Our study aimed to investigate the association between chronic endometritis (CE) and thyroid peroxidase antibody (TPOAb) positivity, and to evaluate the effect of antibiotic therapy on assisted reproductive technology (ART) outcomes in patients with TPOAb-positive CE. A total of 1,385 women undergoing ART were enrolled and categorized into TPOAb-negative (n = 1,240) and TPOAb-positive (n = 145) groups. The prevalence of CE was significantly higher in the TPOAb-positive group compared with the TPOAb-negative group (62.76% vs. 43.47%, p < 0.001). At our center, patients diagnosed with CE routinely received antibiotic therapy prior to ART. In subgroup analyses restricted to CE patients, with clinical pregnancy rate (CPR) and live birth rate (LBR) as the primary outcomes, TPOAb-positive patients with CE who received antibiotics showed significantly higher CPR (52.75% vs. 41.37%, p = 0.0426) and LBR (48.35% vs. 35.44%, p = 0.0184). These associations remained robust after adjustment for potential confounders. In conclusion, TPOAb positivity is linked to a higher prevalence of CE, and antibiotic therapy prior to ART improves reproductive outcomes in TPOAb-positive patients with CE.

Indexed as

Anti-Bacterial AgentsEndometritisIodide PeroxidaseReproductive Techniques, AssistedAdultChronic DiseaseFemaleHumansPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeAnti-Bacterial AgentsIodide PeroxidaseAssisted reproductive technologyChronic endometritisClinical pregnancy rateLive birth rateThyroid autoimmunityThyroid peroxidase antibody

Identifiers

PMID41436709

DOI10.1016/j.jri.2020.103118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.