Evidence map›Paper›PMID 41436700›Full record

ArticleNeuroscience bulletin2026

A Novel Long-range Excitatory Neural Circuit from the Magnocellular Red Nucleus to Spinal Dorsal Horn Facilitates Neuropathic Pain-like Behaviors in Male Mice.

Jiali Shi, Yinfeng Yuan, Yuhao Luo, Yue Guo, Jiashu Lian, Lin Lin, Danni Chen, Qian Wang, Xiumin Xue, Zhichao Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Big Rewards, Fast Learning.Neuroscience bulletin · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiali Shi *School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Yinfeng Yuan *School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Yuhao Luo *School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.ORCID http://orcid.org/0000-0002-9392-5760
Yue GuoSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Jiashu LianDepartment of Ultrasound, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Lin LinSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Danni ChenSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Qian WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Xiumin XueSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Zhichao ChenSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China.
Yongjie WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China. wangyongjie@hznu.edu.cn.ORCID http://orcid.org/0000-0002-0306-3088
Zhihui HuangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, China. huang0069@hznu.edu.cn.ORCID https://orcid.org/0000-0002-1927-0946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropathic pain arises from a primary lesion or disease affecting the somatosensory system; however, the brain circuitry underlying the regulation of neuropathic pain remains unclear. The red nucleus (RN) is a critical brain region involved in regulating muscle tension, coordinating movement, and facilitating sensorimotor integration. While some evidence has shown that RN regulates pain, its specific role in neuropathic pain and associated neural circuits remains elusive. In this study, we found that CaMKIIα-positive neurons in the magnocellular red nucleus (RMC

Indexed as

NeuralgiaRed NucleusSpinal Cord Dorsal HornAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2HyperalgesiaMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsOptogeneticsCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseChemogeneticsMagnocellular red nucleusNeural circuitNeuropathic painOptogeneticsSpinal dorsal horn

Identifiers

PMID41436700
PMCPMC13221545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.