Evidence map›Paper›PMID 41436692›Full record

ArticleInfectious diseases and therapy2026

Novel Diagnostic Marker Interleukin-33 for Invasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure: A Proof-of-Concept Prospective Study.

Lanyue Huang, Meng Zhang, Wei Liu, Yunhui Liu, Liang Chen, Yuxin Niu, Yuzhao Feng, Qiuyu Cheng, Tingting Liu, Peng Wang and 5 more

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Article in Infectious diseases and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lanyue Huang *Department of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Meng Zhang *Department of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Wei LiuDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yunhui LiuDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Liang ChenDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yuxin NiuDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yuzhao FengDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Qiuyu ChengDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Tingting LiuDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Peng WangDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Mi SongDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Guang ChenDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Lin ZhuDepartment of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Tao Chen *Department of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. chentao_tjh@vip.sina.com.ORCID http://orcid.org/0000-0001-6590-7162
Qin Ning *Department of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

Funding

Key Technologies Research and Development Program 2021YFC2600200
6 · The paper itself

Abstract

introductionInvasive pulmonary aspergillosis (IPA) is a life-threatening complication in patients with acute-on-chronic liver failure (ACLF). Cytokines play essential roles in the pathogenesis of IPA and have been identified as promising diagnostic biomarkers. This study aimed to conduct a comprehensive proof-of-concept evaluation of the diagnostic potential of cytokines for IPA in patients with ACLF.

methodsIn this single-center prospective study, patients with HBV-ACLF were categorized into IPA (with diagnostic criteria of probable IPA, n = 16), bacterial pneumonia (BP, n = 32), and non-infection (n = 32) groups. Groups were matched for age, gender, and liver decompensation severity. Plasma cytokines, interleukin (IL)-33, IL-17A, IL-23, IL-31, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-13, interferon-γ, tumor necrosis factor alpha, and soluble IL-2 receptor, were quantified. Diagnostic accuracy was assessed via ROC analysis.

resultsIL-33 levels were markedly elevated in IPA vs. BP (163.07 [108.30-211.22] vs. 12.82 [4.24-50.55] pg/mL; P < 0.001) and non-infection groups (163.07 [108.30-211.22] vs. 4.24 [4.24-52.51] pg/mL; P < 0.001). ROC analysis identified IL-33 as a strong diagnostic marker for IPA (AUC = 0.871; sensitivity 93.80%, specificity 84.40%; P < 0.001) with optimal cutoff at 66.97 pg/mL. Furthermore, IL-33 levels were significantly elevated during IPA development compared to both the incubation phase (154.86 vs. 8.29 pg/mL, P = 0.005) and the recovery phase (154.86 vs. 28.01 pg/mL, P = 0.038).

conclusionsPlasma IL-33 demonstrates high accuracy in diagnosing IPA and differentiating it from bacterial infections in patients with HBV-ACLF, offering a minimally invasive diagnostic tool. Graphical abstract available for this article.

Indexed as

Acute-on-chronic liver failureBacterial pneumoniaBiomarkerCytokinesDifferential diagnosisFungal infectionHBVInterleukin-33Invasive pulmonary aspergillosis

Identifiers

PMID41436692
PMCPMC12855646

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