Evidence map›Paper›PMID 41436666›Full record

ArticleBiogerontology2025

Synergistic effects of 3-O-methylquercetin and polyphenols on longevity, healthspan, and neuroprotection via FOXO/Nrf2.

Péterson Alves Santos, Pricila Pflüger, Juliana Bonnes Bielavski, Gabriel Osório Varriento, Marilise Brittes Rott, Ionara Rodrigues Siqueira, Patrícia Pereira

Abstract read
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In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Péterson Alves SantosLaboratory of Neuropharmacology and Preclinical Toxicology, Institute of Basic Health Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, 90050-170, Brazil.ORCID 0000-0003-3840-7343
Pricila PflügerLaboratory of Neuropharmacology and Preclinical Toxicology, Institute of Basic Health Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, 90050-170, Brazil.ORCID 0000-0002-6067-1266
Juliana Bonnes BielavskiLaboratory of Neuropharmacology and Preclinical Toxicology, Institute of Basic Health Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, 90050-170, Brazil.ORCID 0009-0000-0868-4257
Gabriel Osório VarrientoLaboratory of Neuropharmacology and Preclinical Toxicology, Institute of Basic Health Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, 90050-170, Brazil.ORCID 0009-0006-0562-9723
Marilise Brittes RottInstitute of Basic Health Sciences (ICBS), Federal University of Rio Grande Do Sul, Porto Alegre, 90050-170, Brazil.ORCID 0000-0002-5227-4594
Ionara Rodrigues SiqueiraInstitute of Basic Health Sciences (ICBS), Federal University of Rio Grande Do Sul, Porto Alegre, 90050-170, Brazil.ORCID 0000-0002-4460-0978
Patrícia PereiraLaboratory of Neuropharmacology and Preclinical Toxicology, Institute of Basic Health Sciences, Federal University of Rio Grande Do Sul, Porto Alegre, 90050-170, Brazil. patriciapereira@ufrgs.br.ORCID 0000-0001-7987-1359

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304870/2022-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.506777/2020-00
6 · The paper itself

Abstract

Polyphenols are emerging as promising candidates for promoting healthy aging and neuroprotection. Here, we investigated the effects of quercetin (Q), luteolin (L), and 3-O-methylquercetin (3OMQ), individually and in combination (FORM), on lifespan, healthspan, and neurobehavioral functions in Caenorhabditis elegans. Wild-type and mutant strains (including daf-2, daf-16, and skn-1) were exposed to the compounds, followed by assessments of longevity, motility, senescence biomarkers (lipofuscin and red autofluorescence), and neuroprotection against PTZ- and methylmercury-induced damage. 3OMQ and FORM significantly extended lifespan (+ 20-24%) and improved motility and stress resilience, with effects dependent on the DAF-16/FOXO and SKN-1/Nrf2 pathways, but independent of DAF-2/IGF1R signalling. Both compounds induced DAF-16 nuclear translocation and upregulated SKN-1 expression. Furthermore, they attenuated neurodegeneration and cholinesterase hyperactivity following manganese and methylmercury exposure. These findings support the potential of 3OMQ and its polyphenol combination as anti-aging and neuroprotective agents, acting through conserved longevity and oxidative stress pathways.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsLongevityNeuroprotectionNeuroprotective AgentsNF-E2-Related Factor 2PolyphenolsQuercetinAnimalsDNA-Binding ProteinsDrug SynergismLuteolinSignal TransductionTranscription FactorsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDNA-Binding ProteinsForkhead Transcription FactorsLuteolinNeuroprotective AgentsNF-E2-Related Factor 2PolyphenolsQuercetinskn-1 protein, C elegansTranscription FactorsAgingCaenorhabditis elegansNeuroprotectionPolyphenols

Identifiers

PMID41436666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.