Evidence map›Paper›PMID 41436620›Full record

ArticleScientific reports2025

Antiproliferative activity of Moringa oleifera (L.) Lam. and Moringa stenopetala (Bak.) Cufod. leaves extract against selected cancer cells in primary cell culture.

Masresha Ahmed Assaye, Poupak Fallahi, Duccio Volterrani, Silvia Martina Ferrari, Emilio Barozzi, Armando Patrizio, Hagos Tesfay, Solomon Genet Gebre

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Masresha Ahmed AssayeDepartment of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. masresha.ahmed@aau.edu.et.ORCID http://orcid.org/0000-0002-5392-0789
Poupak FallahiDepartment of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Duccio Volterrani *Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Silvia Martina FerrariDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Emilio BarozziDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Armando PatrizioDepartment of Emergency Medicine, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Hagos Tesfay *Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Solomon Genet Gebre *Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. solgen73@yahoo.com.ORCID http://orcid.org/0000-0002-5433-0107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural compounds possess anti-tumor capabilities for a wide range of cancers. The present study aims to analyze and compare the antiproliferative activity of Moringa oleifera and Moringa stenopetala leaf extracts against anaplastic thyroid carcinoma and lung adenocarcinoma cells in primary cell culture. Samples were collected from Arba Minch, Ethiopia. Water-soluble tetrazolium salt-1 assay was used to assess the antiproliferative activity of these samples against anaplastic thyroid carcinoma and lung adenocarcinoma cells in primary cell culture. Cell number counting was another method used to confirm cell proliferation. The results showed that, in comparison to the control, both Moringa species significantly lowered cancer cell proliferation in a dose-responsive manner. Although Moringa oleifera showed a stronger inhibitory effect compared to Moringa stenopetala, there was no statistically significant difference (p > 0.05) in the proliferation of anaplastic thyroid carcinoma and lung adenocarcinoma cells between the two species. Moringa oleifera extract had a lower IC50 value in anaplastic thyroid carcinoma cells, 84.2 µg/ml, than Moringa stenopetala leaf extract, 90.6 µg/ml. Moringa oleifera leaf extract has a lower IC50 value in lung adenocarcinoma cells, 64.7 µg/ml, than Moringa stenopetala leaf extract, 75.3 µg/ml. In conclusion, the two species have antiproliferative activity on anaplastic thyroid carcinoma and lung adenocarcinoma cells in primary cell culture. These findings indicated that both extracts may serve as a basis for future cancer therapeutic applications.

Indexed as

Antineoplastic Agents, PhytogenicCell ProliferationMoringaMoringa oleiferaPlant ExtractsPlant LeavesCell Line, TumorHumansPrimary Cell CultureThyroid Carcinoma, AnaplasticAntineoplastic Agents, PhytogenicPlant ExtractsAntiproliferativeCancerMoringa oleiferaMoringa stenopetalaPrimary cell culture

Identifiers

PMID41436620
PMCPMC12847886

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