Spatial interaction between retinal and choroidal circulation in retinal vein occlusion.

SolAh Han, Sang Uk Choi, Yoon Jeon Kim, Young Hee Yoon, Junyeop Lee

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

SolAh HanDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Sang Uk ChoiDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Yoon Jeon KimDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Young Hee YoonDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Junyeop LeeDepartment of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea. j.lee@amc.seoul.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal vein occlusion (RVO) is a leading cause of vision loss, yet the interaction between retinal and choroidal circulation in this condition remains incompletely understood. This retrospective, cross-sectional study aimed to quantitatively evaluate choroidal structural changes in treatment-naïve unilateral RVO using ultra-widefield imaging. Twenty-nine patients with unilateral branch or central RVO and their unaffected fellow eyes were analyzed. Mean choroidal thickness (MCT) and choroidal vascular index (CVI) were measured on widefield swept-source optical coherence tomography, while choroidal vascular density (CVD) and choroidal vascular fractal dimension (CFD) were calculated from ultra-widefield indocyanine green angiography (UWF-ICGA) images using binarization and fractal analysis protocols. Compared with fellow eyes, RVO eyes demonstrated significantly increased MCT (254.48 ± 60.72 μm vs. 230.68 ± 60.47 μm, P = 0.030), CVI (64.85 ± 3.38 vs. 61.88 ± 4.34, P = 0.011), and CVD (62.24 ± 2.87 vs. 60.01 ± 3.41, P = 0.038), whereas CFD was reduced (1.77 ± 0.02 vs. 1.82 ± 0.02, P < 0.001). Sub-quadrant analysis in branch RVO revealed that choroidal vascular changes were localized to the affected quadrant, with significantly higher CVD and lower CFD than the corresponding quadrants in the same and fellow eyes. These findings suggest that RVO induces regional choroidal vascular remodeling, possibly mediated by VEGF-driven vasodilation and inflammatory pathways, supporting a spatially localized interaction between retinal and choroidal circulation in acute retinal vascular occlusion.

Indexed as

ChoroidRetinaRetinal Vein OcclusionRetinal VesselsAgedCross-Sectional StudiesFemaleFluorescein AngiographyHumansMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceChoroidal vascular densityChoroidal vascular fractal dimensionChoroidal vascular remodelingRetinal vein occlusionUltra-widefield imaging

Identifiers

PMID41436571

DOI10.1038/s41598-025-33054-y

PMCPMC12830589

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.