Evidence map›Paper›PMID 41436564›Full record

ArticleScientific reports2025

Validated Erythrosin B spectrofluorimetric method for ganciclovir bioanalysis in rabbit plasma following valganciclovir bioconversion and Pharmacokinetic application.

Ali Alqahtani, Taha Alqahtani, Adil Alshehri, Ahmed A Almrasy

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ali AlqahtaniDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia.
Taha AlqahtaniDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia.
Adil AlshehriDepartment of Medicine, College of Medicine, King Khalid University, Abha, 62529, Saudi Arabia.
Ahmed A AlmrasyPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, 11751, Egypt. ahmedalialmrasy8@gmail.com.

Funding

Deanship of Research and Graduate Studies at King Khalid University RGP2/384/46
6 · The paper itself

Abstract

A novel, environmentally sustainable spectrofluorimetric method was developed and validated for sensitive determination of ganciclovir in rabbit plasma following valganciclovir administration. The method is based on fluorescence quenching of Erythrosin B probe through static complex formation with ganciclovir, as confirmed by comprehensive spectroscopic characterization using UV-visible absorption and fluorescence spectroscopy. Furthermore, temperature-dependent Stern-Volmer analysis revealed static quenching mechanism with Stern-Volmer constants decreasing from 3.77 × 10

Indexed as

Antiviral AgentsErythrosineGanciclovirValganciclovirAnimalsRabbitsReproducibility of ResultsSpectrometry, FluorescenceThermodynamicsAntiviral AgentsErythrosineGanciclovirValganciclovirBioanalytical validationErythrosin BGanciclovirPharmacokineticsSpectrofluorimetry

Identifiers

PMID41436564
PMCPMC12739150

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.