Synthesis, spectral, thermal, and biological characterization of Se(IV) nanocomplexes derived from vitamin E and amino acid mixed ligands as a metal-drug model.

Mohamed Y El-Sayed, Ibrahim M A Alatawy, Hazim M Ali, Tamer H A Hasanin, I M Ahmed, Moamen S Refat, Kareem A Asla

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Mohamed Y El-SayedDepartment of Chemistry, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia. myelsayed@ju.edu.sa.

Ibrahim M A AlatawyDepartment of Chemistry, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia.

Hazim M AliDepartment of Chemistry, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia.

Tamer H A HasaninDepartment of Chemistry, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia.

I M AhmedDepartment of Chemistry, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia.

Moamen S RefatDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.

Kareem A AslaDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt. dr.kasla2020@gmail.com.

Funding

This work was funded by the Deanship of Graduate Studies and Scientific Research at Jouf University DGSSR-2025-FC-01061Wellcome Trust FC001061

6 · The paper itself

Abstract

Researchers have been interested in inorganic pharmaceutical chemistry in recent years. They have prepared antioxidants and anticancer compounds to lower the cost of manufacturing platinum and palladium medications and as alternatives to some known side-effect drugs. The current work focused on selenium complexes with mixed ligands, which included histidine, tryptophan, and tyrosine as the second ligand and one of the interesting vitamins, like vitamin E, as the first ligand. The synthesis was done in a molar ratio of (1:2:1) (selenium: vitamin E: amino acid). Different characterization techniques were used to check and discuss the chemical structures and morphological properties of the synthesized complexes, including elemental analysis, conductance, FTIR, XRD, UV-Vis, TG/DTG,

Indexed as

Amino AcidsCoordination ComplexesSeleniumVitamin EAntineoplastic AgentsAntioxidantsCell Line, TumorHumansLigandsAmino AcidsAntineoplastic AgentsAntioxidantsCoordination ComplexesLigandsSeleniumVitamin EAmino acidsAntioxidant activityCytotoxicityMixed ligand nanocomplexSe(IV)Vitamin e

Identifiers

PMID41436536

DOI10.1038/s41598-025-30281-1

PMCPMC12780159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.