Evidence map›Paper›PMID 41436468›Full record

ArticleNature communications2025

A brain-to-small intestine circuit mediates morphine-induced constipation in male mice.

Jun Ma, Xiaoqi Peng, Mingjun Zhang, Wei Gao, Xinlu Yang, Zerui Wang, Xiaoqing Chai, Zhi Zhang, Sheng Wang, Peng Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun Ma *Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xiaoqi Peng *Department of Pain Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Mingjun Zhang *Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230026, Hefei, China.
Wei GaoDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xinlu YangDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Zerui WangHefei No.1 High School, Heifei, China.
Xiaoqing ChaiDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. xiaoqingchai@ustc.edu.cn.
Zhi ZhangDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhizhang@ustc.edu.cn.ORCID http://orcid.org/0000-0002-4205-3181
Sheng WangDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. iamsheng2020@ustc.edu.cn.
Peng CaoDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230026, Hefei, China. pengcao@ustc.edu.cn.ORCID http://orcid.org/0009-0001-6712-429X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32025017, 32121002, 32241013National Natural Science Foundation of China (National Science Foundation of China) 32400824, 32522044, U24A20702
6 · The paper itself

Abstract

Opioid-induced constipation is one of the most common and persistent side effect of opioid analgesics, yet the underlying neural mechanism(s) remain unclear. Here we show morphine-induced constipation is mediated by a neural circuit from glutamatergic neurons in the paraventricular nucleus of hypothalamus (PVN

Indexed as

Analgesics, OpioidBrainConstipationIntestine, SmallMorphineOpioid-Induced ConstipationAnimalsGastrointestinal MotilityMaleMiceMice, Inbred C57BLNeuronsParaventricular Hypothalamic NucleusReceptors, N-Methyl-D-AspartateReceptors, Opioid, muVagus NerveAnalgesics, OpioidMorphineReceptors, N-Methyl-D-AspartateReceptors, Opioid, mu

Identifiers

PMID41436468
PMCPMC12847740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.